Reversal of amblyopia in lambs

We have tried to reverse the effects of shutting one eye in lambs firstly by the use of the CAM stimulator for one hour and secondly by the administration of 4-aminopyridine. Of these 4-aminopyridine produces rather greater recovery than the CAM stimulator, provided the eye has not been closed for more than 15 to 20 days. After this time neither method produces any measurable improvement under our conditions.