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Prevention and Treatment of Intestinal Failure-Associated Liver Disease in Children

Lorenzo Norsa1, Emanuele Nicastro2, Angelo Di Giorgio3

  • 1Pediatric Gastroenterology Hepatology and Nutrition, Ospedale Papa Giovanni XXIII, 24127 Bergamo, Italy. lnorsa@asst-pg23.it.

Nutrients
|June 9, 2018
PubMed

Insights

Intestinal failure-associated liver disease (IFALD) in children is a serious complication of long-term parenteral nutrition. Early management and prevention strategies are crucial for managing IFALD and avoiding liver transplantation.

Area of Science:

  • Pediatric Gastroenterology
  • Hepatology
  • Intestinal Rehabilitation

Background:

  • Intestinal failure-associated liver disease (IFALD) poses a significant threat to children requiring long-term parenteral nutrition.
  • Progressive IFALD can impede intestinal rehabilitation and necessitate combined liver-intestinal transplantation.
  • Dedicated intestinal failure centers have successfully reduced IFALD incidence.

Purpose of the Study:

  • To review the etiology and risk factors of IFALD.
  • To highlight key prevention strategies, including nutritional management and infection control.
  • To discuss current and emerging therapeutic interventions for IFALD.

Main Methods:

  • Literature review of IFALD etiology, risk factors, prevention, and treatment.
  • Analysis of evidence from dedicated intestinal failure centers.
  • Synthesis of current medical and surgical treatment strategies.

Main Results:

  • Early and proactive management can prevent IFALD progression to end-stage liver disease.
  • Nutritional optimization and strict control of catheter-related infections are primary preventive measures.
  • Timely intervention can lead to the resolution of IFALD.

Conclusions:

  • IFALD is a preventable complication with appropriate management.
  • Multidisciplinary care in intestinal failure centers is vital for IFALD prevention and treatment.
  • Further research into advanced therapeutic strategies is ongoing.

Keywords:
childrenintestinal failureliver diseaseparenteral nutritionpreventiontreatment

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