Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Viral Recombination00:57

Viral Recombination

25.2K
Cells are sometimes infected by more than one virus at once. When two viruses disassemble to expose their genomes for replication in the same cell, similar regions of their genomes can pair together and exchange sequences in a process called recombination. Alternatively, viruses with segmented genomes can swap segments in a process called reassortment.
25.2K
Viral Structure00:56

Viral Structure

74.7K
Viruses are extraordinarily diverse in shape and size, but they all have several structural features in common. All viruses have a core that contains a DNA- or RNA-based genome. The core is surrounded by a protective coat of proteins called the capsid. The capsid is composed of subunits called capsomeres. The capsid and genome-containing core are together known as the nucleocapsid.
74.7K
Vectors01:30

Vectors

488
Vectors are mathematical entities characterized by both magnitude and direction. Unlike scalars, which are defined solely by magnitude, vectors represent quantities like displacement, velocity, and force, where direction is essential. Vectors are graphically represented as directed line segments, extending from an initial point to a terminal point, denoted with bold letters or arrows placed above the symbol. Two vectors are deemed equal if they share identical magnitudes and directions,...
488
Group Therapy01:26

Group Therapy

451
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
451
Acceleration Vectors01:30

Acceleration Vectors

23.1K
In everyday conversation, accelerating means speeding up. Acceleration is a vector in the same direction as the change in velocity, Δv, therefore the greater the acceleration, the greater the change in velocity over a given time. Since velocity is a vector, it can change in magnitude, direction, or both. Thus acceleration is a change in speed or direction, or both. For example, if a runner traveling at 10 km/h due east slows to a stop, reverses direction, and continues their run at 10 km/h...
23.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Novel approach for vaccine delivery using mRNA lipid nanoparticles for <i>in vivo</i> production of monoclonal antibodies.

Molecular therapy. Nucleic acids·2026
Same author

The XEC Variant: Genomic Evolution, Immune Evasion, and Public Health Implications.

Viruses·2025
Same author

Methuselah proteins in Drosophila: Structural and evolutionary insights from mathematical genomics.

Biochemical and biophysical research communications·2025
Same author

Improved SARS-CoV-2 vaccine based on intranasally administered replicon RNA.

Molecular therapy : the journal of the American Society of Gene Therapy·2025
Same author

Viral Vector-Based Cancer Vaccines.

Methods in molecular biology (Clifton, N.J.)·2025
Same author

Immunobiology and immunotherapy of COVID-19.

Progress in molecular biology and translational science·2025

Related Experiment Video

Updated: Feb 9, 2026

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
06:48

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

22.2K

Viral Vectors in Gene Therapy.

Kenneth Lundstrom1

  • 1PanTherapeutics, CH1095 Lutry, Switzerland. lundstromkenneth@gmail.com.

Diseases (Basel, Switzerland)
|June 9, 2018
PubMed
Summary

Viral vectors are revolutionizing gene therapy, offering new treatments for diverse diseases including cancer. Advances in engineering and safety have led to approved therapies and promising clinical trial results.

Area of Science:

  • Biotechnology and Gene Therapy
  • Molecular Medicine
  • Immunotherapy

Background:

  • Viral vectors have emerged as a significant tool in modern medicine, particularly for gene therapy applications.
  • Improvements in vector engineering, delivery methods, and safety profiles have enhanced their therapeutic potential.
  • These vectors are being explored for a wide range of conditions, including metabolic, cardiovascular, muscular, hematologic, and ophthalmologic diseases, as well as various cancers.

Purpose of the Study:

  • To highlight the recent advancements and broad applicability of viral vector technology in gene therapy.
  • To discuss the role of viral vectors in immunotherapy and gene silencing strategies.
  • To summarize the preclinical and clinical evidence supporting the efficacy and safety of viral vector-based treatments.
Keywords:
approved drugsclinical trialsgene silencingimmunotherapypreventiontherapy

More Related Videos

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

5.3K
Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
08:33

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Published on: February 28, 2016

13.8K

Related Experiment Videos

Last Updated: Feb 9, 2026

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium
06:48

Limbal Approach-Subretinal Injection of Viral Vectors for Gene Therapy in Mice Retinal Pigment Epithelium

Published on: August 7, 2015

22.2K
Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants
09:20

Isolation of Next-Generation Gene Therapy Vectors through Engineering, Barcoding, and Screening of Adeno-Associated Virus AAV Capsid Variants

Published on: October 18, 2022

5.3K
Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector
08:33

Development of an Alpha-synuclein Based Rat Model for Parkinson's Disease via Stereotactic Injection of a Recombinant Adeno-associated Viral Vector

Published on: February 28, 2016

13.8K

Main Methods:

  • Review of recent literature on viral vector development and applications.
  • Analysis of preclinical studies in animal models demonstrating therapeutic and prophylactic effects.
  • Examination of data from clinical trials and approved viral vector-based drugs.

Main Results:

  • Viral vector technology has shown significant progress, leading to its forefront position in gene therapy.
  • Applications span numerous disease categories, including cancer and immunotherapy.
  • Gene silencing using viral vectors offers a reversible therapeutic approach.
  • Preclinical and clinical studies confirm the efficacy and safety of these vectors.
  • Several viral vector-based drugs have received global approval.

Conclusions:

  • Viral vectors represent a powerful and increasingly safe platform for gene therapy.
  • Their versatility supports treatment for a wide spectrum of diseases and novel therapeutic strategies like immunotherapy and gene silencing.
  • The growing number of approved drugs underscores the clinical success and therapeutic promise of viral vector technology.