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Hunting for Treasure Chests in Microbial Defense Islands
1National Center for Biotechnology Information, National Library of Medicine, Bethesda, MD 20894, USA.
Abstract:
Microbes exist in a constant struggle with viruses and have evolved multiple defense mechanisms. Some of these, such as restriction endonucleases and CRISPR-Cas, have revolutionized genome editing methodology. A systematic strategy combining computation and experiment led to discovery of ten new defense systems that remain to be characterized mechanistically.
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