Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-patch Base Excision Repair

Long-patch Base Excision Repair

Since the discovery of the two BER pathways, there has been a debate about how a cell chooses one pathway over the other and the factors determining this selection. Numerous in vitro experiments have pointed out multiple determinants for the sub-pathway selection. These are:

Base Excision Repair

Base Excision Repair

One of the common DNA damages is the chemical alteration of single bases by alkylation, oxidation, or deamination. The altered bases cause mispairing and strand breakage during replication. This type of damage causes minimal change to the DNA double helix structure and can be repaired by the base excision repair (BER) pathways. BER corrects damaged DNA sequences by removing the damaged base and restoring the original base sequence using the complementary strand as a template.
The first step of...

Fixing Double-strand Breaks

Fixing Double-strand Breaks

The double-stranded structure of DNA has two major advantages. First, it serves as a safe repository of genetic information where one strand serves as the back-up in case the other strand is damaged. Second, the double-helical structure can be wrapped around proteins called histones to form nucleosomes, which can then be tightly wound to form chromosomes. This way, DNA chains up to 2 inches long can be contained within microscopic structures in a cell. A double-stranded break not only damages...

Overview of DNA Repair

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...

Mismatch Repair

Mismatch Repair

Nucleotide Excision Repair

Nucleotide Excision Repair

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Contemporary Outcomes of Temporary Mechanical Circulatory Support Use in Ischemic Ventricular Septal Defect: A U.S. Multi-Center Analysis.

The Annals of thoracic surgery·2026

Same author

Emergency All-Arterial Anaortic Off-Pump Coronary Artery Bypass Grafting for Acute Coronary Syndrome in a 52-Year-Old Patient with a Childhood History of Kawasaki Disease.

Surgical case reports·2026

Same author

Aortic root replacement after repaired congenital conotruncal defects: A surgical challenge.

JTCVS open·2026

Same author

Incidence of Venous Thromboembolism After Surgery for Acute Stanford Type A Aortic Dissection.

Cureus·2026

Same author

Trends of clinical vertebral and hip fractures following local government involvement in fracture prevention from 2015 to 2021 in Kure, Japan.

Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·2026

Same author

Bilateral versus single internal mammary artery use in patients with chronic kidney disease.

General thoracic and cardiovascular surgery·2026

Search research articles

Related Experiment Video

Updated: Feb 9, 2026

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

Modified Double Patch Repair for Septal Rupture With Ventricular Wall Dissection.

Takuma Yamasaki¹, Yuichi Matsuzaki¹, Yu Hohri¹

¹Department of Cardiovascular Surgery, Japanese Red Cross Kyoto Daini Hospital, Kyoto, Japan.

The Annals of Thoracic Surgery

|June 9, 2018

Summary

Ventricular septal rupture with free wall dissection is rare after inferior myocardial infarction. A modified double patch repair technique effectively excluded dissection, preventing residual shunts and preserving cardiac function.

Area of Science:

Cardiology
Cardiac Surgery
Cardiovascular Imaging

Background:

Ventricular septal rupture (VSR) with ventricular free wall dissection is a rare but severe complication following inferior myocardial infarction.

More Related Videos

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Published on: September 8, 2010

Related Experiment Videos

Last Updated: Feb 9, 2026

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart

Published on: April 15, 2020

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Reduction in Left Ventricular Wall Stress and Improvement in Function in Failing Hearts using Algisyl-LVR

Published on: April 8, 2013

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Analysis of DNA Double-strand Break DSB Repair in Mammalian Cells

Published on: September 8, 2010

Optimal surgical management for this condition is not well-established due to limited case numbers and survival data.