Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

6.6K
Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
6.6K
Structure of Lipids03:38

Structure of Lipids

99.1K
Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
99.1K
What are Lipids?01:38

What are Lipids?

220.8K
Overview
220.8K
Acids, Bases and Neutralization Reactions03:26

Acids, Bases and Neutralization Reactions

63.9K
An acid-base reaction is one in which a hydrogen ion, H+, is transferred from one chemical species to another. Such reactions are of central importance to numerous natural and technological processes, ranging from the chemical transformations within cells or lakes and oceans to the industrial-scale production of fertilizers, pharmaceuticals, and other substances essential to the society.
63.9K
Lipid Digestion01:06

Lipid Digestion

99.6K
Lipids are large molecules that are generally not water-soluble. Since most of the digestive enzymes in the human body are water-based, there are specific steps the body must take to break down lipids and make them available for use.
99.6K
What is Population Genetics?01:25

What is Population Genetics?

64.8K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Adipose Triglyceride Lipase Knockout Increases Anticontractile Effects of Perivascular Adipose Tissue.

Arteriosclerosis, thrombosis, and vascular biology·2025
Same author

Erratum to 'Inhibition of ATGL alleviates MASH via impaired PPARa signalling that favours hydrophilic bile acid composition in mice' [J Hepatol 82 (2025) 658-675].

Journal of hepatology·2025
Same author

Defective targeting of PNPLA1 to lipid droplets causes ichthyosis in ABHD5-syndromic epidermal differentiation disorder.

Journal of lipid research·2025
Same author

Reduced Esterification Rather Than Increased Hydrolysis Is Causative for Loss of Hepatic Retinoids Upon CCl<sub>4</sub>-Induced Liver Injury.

Liver international : official journal of the International Association for the Study of the Liver·2025
Same author

Functionally overlapping intra- and extralysosomal pathways promote bis(monoacylglycero)phosphate synthesis in mammalian cells.

Nature communications·2024
Same author

Phospholipase A2 group IVD mediates the transacylation of glycerophospholipids and acylglycerols.

Journal of lipid research·2024

Related Experiment Video

Updated: Feb 9, 2026

A Preclinical Murine Model of Hepatic Metastases
06:51

A Preclinical Murine Model of Hepatic Metastases

Published on: September 27, 2014

30.4K

Genetically modified mouse models to study hepatic neutral lipid mobilization.

Guenter Haemmerle1, Achim Lass2

  • 1Institute of Molecular Biosciences, University of Graz, Heinrichstraße 31/II, 8010 Graz, Austria.

Biochimica Et Biophysica Acta. Molecular Basis of Disease
|June 9, 2018
PubMed
Summary

Non-alcoholic fatty liver disease (NAFLD) involves harmful triacylglycerol buildup. Understanding enzymes that mobilize neutral lipid esters is key to developing therapies for liver steatosis, fibrosis, and cirrhosis.

Keywords:
CholesterolFibrosisLipaseLiverNeutral lipid metabolismNon-alcoholic fatty liver diseaseRetinolSteatosisTriacylglycerolVitamin A

More Related Videos

A Simple and Rapid Protocol for Measuring Neutral Lipids in Algal Cells Using Fluorescence
10:56

A Simple and Rapid Protocol for Measuring Neutral Lipids in Algal Cells Using Fluorescence

Published on: May 30, 2014

36.7K
Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells
08:37

Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells

Published on: March 10, 2023

3.4K

Related Experiment Videos

Last Updated: Feb 9, 2026

A Preclinical Murine Model of Hepatic Metastases
06:51

A Preclinical Murine Model of Hepatic Metastases

Published on: September 27, 2014

30.4K
A Simple and Rapid Protocol for Measuring Neutral Lipids in Algal Cells Using Fluorescence
10:56

A Simple and Rapid Protocol for Measuring Neutral Lipids in Algal Cells Using Fluorescence

Published on: May 30, 2014

36.7K
Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells
08:37

Author Spotlight: Evaluation of Lipid Droplet Size and Fusion in Bovine Hepatic Cells

Published on: March 10, 2023

3.4K

Area of Science:

  • Hepatology
  • Molecular Biology
  • Biochemistry

Background:

  • Non-alcoholic fatty liver disease (NAFLD) is characterized by excessive hepatic triacylglycerol accumulation, progressing to steatohepatitis, fibrosis, and cirrhosis.
  • Dysregulation of neutral lipid ester metabolism, including cholesteryl and retinyl esters, contributes to severe liver pathologies.
  • Understanding the enzymes involved in neutral lipid ester mobilization is critical for therapeutic development.

Purpose of the Study:

  • To review the physiological roles of enzymes that mobilize neutral lipid esters in liver cells.
  • To highlight the importance of controlling lipid metabolism for preventing liver disease progression.

Main Methods:

  • Literature review focusing on enzymes governing neutral lipid ester mobilization.
  • Analysis of pathways involved in lipid metabolism within liver cells (cytosolic lipid droplets, ER, lysosomes).

Main Results:

  • Hepatic steatosis results from imbalanced lipid metabolism, including uptake, synthesis, hydrolysis, secretion, and oxidation.
  • Aberrant accumulation of cholesteryl esters leads to severe conditions like Wolman disease.
  • Loss of retinyl ester stores is linked to liver fibrosis onset.

Conclusions:

  • Targeting enzymes that mobilize neutral lipid esters offers potential therapeutic strategies for NAFLD and its advanced stages.
  • Maintaining tight control over hepatic neutral lipid ester metabolism is essential for liver health.
  • Further research into these enzymatic pathways is crucial for ameliorating liver disease.