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Updated: Feb 9, 2026

A Quantitative Measurement of Reactive Oxygen Species and Senescence-associated Secretory Phenotype in Normal Human Fibroblasts During Oncogene-induced Senescence
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Musculoskeletal senescence: a moving target ready to be eliminated

Marjolein P Baar1, Eusebio Perdiguero2, Pura Muñoz-Cánoves3

  • 1Department of Molecular Cancer Research, Center for Molecular Medicine, Division of Biomedical Genetics, University Medical Center Utrecht, Utrecht University, Universiteitsweg 100, 3584CG Utrecht, The Netherlands; Department of Molecular Genetics, Erasmus University Medical Center, Rotterdam, The Netherlands.

Current Opinion in Pharmacology
|June 9, 2018
PubMed

Insights

Cellular senescence, a hallmark of aging, contributes to frailty and disease. Targeting senescent cells shows promise for restoring tissue health and treating age-related conditions.

Area of Science:

  • Gerontology
  • Cellular Biology
  • Molecular Medicine

Background:

  • Aging is the primary risk factor for numerous diseases.
  • Frailty is a key indicator of aging, influencing therapeutic risk-benefit assessments.
  • Cellular senescence, arising from molecular damage, impairs tissue function through secreted factors.

Purpose of the Study:

  • To explore the role of cellular senescence in aging and frailty.
  • To investigate the impact of senescent cells on stem cell function and musculoskeletal aging.
  • To evaluate the therapeutic potential of targeting senescent cells for age-related pathologies.

Main Methods:

  • Analysis of senescent cell markers and their secreted products.
  • Assessment of stem cell function in aged tissues.
  • Experimental induction and targeted elimination of senescent cells in aged animal models.

Main Results:

  • Senescent cells were found to interfere with stem cell function.
  • Evidence suggests senescent cells drive aging of the musculoskeletal system.
  • Targeted removal of senescent cells restored tissue homeostasis in aged animals.

Conclusions:

  • Cellular senescence is a significant contributor to aging and frailty.
  • Targeting senescent cells offers a novel therapeutic strategy for age-related diseases.
  • Intervention in cellular senescence may yield broad health benefits for the elderly.

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