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Related Experiment Video

Updated: Feb 9, 2026

Surgical Closure of Equine Abdomen, Prevention, and Management of Incisional Complications

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Published on: May 10, 2024

Generalized Equine Cutaneous Mastocytosis.

N F Cheville¹, K Prasse¹, M van der Maaten¹

¹National Animal Disease Laboratory, and Iowa State University, Ames, Iowa.

Veterinary Pathology

|June 10, 2018

Summary

A newborn foal experienced generalized cutaneous mastocytosis with skin nodules and bone marrow changes. The mast cell lesions enlarged, ulcerated, and regressed, with histamine present in mast cells.

Area of Science:

Veterinary Pathology
Dermatology
Cell Biology

Background:

Cutaneous mastocytosis is a rare condition in foals.
Mast cell disorders can affect various tissues and organs.

Purpose of the Study:

To describe a case of generalized cutaneous mastocytosis in a newborn foal.
To investigate the histopathological and ultrastructural features of the lesions.
To assess the behavior of mast cells in cell culture.

Main Methods:

Histopathological examination of skin, lymph node, spleen, and bone marrow biopsies.
Ultrastructural analysis of mast cell granules.
In vitro cell culture of mast cells from lesions.

Main Results:

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The foal presented with multifocal, elevated skin nodules composed of mast cells.
Advanced lesions showed eosinophil infiltration, collagen necrosis, and fibroplasia.
Mast cells contained abundant histamine and exhibited mitotic activity in early culture passages.

Conclusions:

This case highlights a unique presentation of generalized cutaneous mastocytosis in a foal.
The spontaneous regression of lesions suggests a dynamic disease process.
Mast cell behavior in culture provides insights into their proliferative potential.