Related Experiment Video
Updated: Feb 9, 2026

Experimental Generation of Carcinoma-Associated Fibroblasts CAFs from Human Mammary Fibroblasts
Published on: October 25, 2011
Canine Malignant Mammary Tumours II. Adenocarcinomas, Solid Carcinomas and Spindle Cell Carcinomas
W Misdorp1, E Cotchin1, J F Hampe1
1Afdeling Pathologic, Nedcrlands Kankerinstituut, Amsterdam; Department of Pathology, Royal Veterinary College, London; Afdeling Pathologie, Binnengasthuis and University of Amsterdam, Amsterdam; Department of Veterinary Paraclinical Sciences, University of Melbourne, Melbourne; Institut für Allgemeine Pathologie und Pathologische Anatomie der Tierärztlichen Fakultät der Universität München, München.
Abstract:
A preliminary classification of 130 canine mammary adenocarcinomas, 76 solid carcinomas, and nine spindle cell carcinomas, together with several subtypes, was constructed from pooled, selected (metastasized) material. Each tumour in this series was classified by subjective assessment of its quantitatively predominant histological picture. Many adenocarcinomas and solid carcinomas of simple type were infiltrative, and lymphatic permeation was often found. The complex types of adenocarcinomas and of solid carcinomas were expansive, and lymphatic permeation was rare. Some metastasized adenocarcinomas were well differentiated. The clinical signs, distribution of metastases and some preliminary data on the times of survival of dogs with various types of carcinomas are discussed.
Related Concept Videos
The Mitotic Spindle
The bipolar configuration of the mitotic spindle facilitates chromosomal segregation, preparing the cell for division. One mechanism that ensures...
Spindle Assembly
In most cells, centrosomes are the primary microtubule nucleation centers. In the centrosome-mediated pathway, the G2-prophase transition triggers centrosome maturation and increased microtubule nucleation. Progressive nucleation results in a...
Structures of Solids
Metallic Solids
All metallic solids exhibit high thermal and electrical conductivity, metallic luster, and malleability....
The Spindle Assembly Checkpoint
Many proteins function together to control the spindle assembly checkpoint. Mutations affecting these proteins may allow cells to proceed into anaphase prematurely, resulting in the...
Network Covalent Solids
To break or to melt a covalent network solid, covalent bonds must be broken. Because covalent bonds are relatively strong, covalent network solids are typically...

