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Updated: Feb 9, 2026
Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy
Published on: November 29, 2015
Proliferative Optic Neuropathy in Horses
L Z Saunders1, S I Bistner1, L F Rubin1
1School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pa.; and the New York State Veterinary College, Ithaca, N.Y.
Abstract:
An asymptomatic, ophthalmoscopically visible proliferation affected the optic disc and nerve of two aged horses. The lesion consisted of an accumulation of foamy cells, histologically akin to fat cells, which contained an unidentified lipid-like material. The affected area and its environs were permeated by tortuous, thickened blood vessels with heavy deposits of collagen in their walls. The neuropathy is considered to be a storage disease, and although the product stored is unidentified, the lesion is similar to that of human xanthelasma. The neuropathy seems distinct from the exudative optic neuritis of horses that has been known since 1890.
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