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Related Experiment Video

Updated: Feb 9, 2026

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Rat Model of Photochemically-Induced Posterior Ischemic Optic Neuropathy

Published on: November 29, 2015

Proliferative Optic Neuropathy in Horses.

L Z Saunders¹, S I Bistner¹, L F Rubin¹

¹School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pa.; and the New York State Veterinary College, Ithaca, N.Y.

Veterinary Pathology

|June 10, 2018

Summary

This summary is machine-generated.

Two aged horses developed an unusual optic nerve condition, characterized by foamy cells and abnormal blood vessels. This storage disease, distinct from other equine optic neuropathies, may resemble human xanthelasma.

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Area of Science:

Veterinary Ophthalmology
Equine Neurology
Comparative Pathology

Background:

Optic nerve lesions in horses can impact vision.
Storage diseases involve the accumulation of abnormal substances within cells.
Xanthelasma is a human condition characterized by lipid deposits.

Purpose of the Study:

To describe a novel optic nerve lesion in two horses.
To characterize the histopathology and potential etiology of the observed neuropathy.
To differentiate this condition from known equine optic neuropathies.

Main Methods:

Ophthalmoscopic examination of affected horses.
Histopathological analysis of optic disc and nerve tissue.
Comparative analysis with human and equine neuropathological conditions.

Main Results:

Identified an asymptomatic proliferation on the optic disc and nerve.
Histology revealed foamy cells containing unidentified lipid-like material.
Affected vessels showed thickening with collagen deposits, suggesting a storage disease.
The lesion was histologically distinct from exudative optic neuritis.

Conclusions:

The observed optic nerve lesion in horses is a distinct storage disease.
The condition involves foamy cells and vascular changes, potentially similar to human xanthelasma.
Further research is needed to identify the stored material and elucidate the pathogenesis.