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Published on: February 13, 2020
Simian Neonatology: I. Gestational Maturity and Extrauterine Viability
R A Price1, Miriam R Anver1, F G Garcia1
1New England Regional Primale Research Center, Harvard Medical School, Southboro, Mass.; and Children's Hospital Medical Center, Boston, Mass.
Neonatal simian mortality was 37%, with most deaths occurring perinatally. Birth weight criteria helped identify high-risk infants in macaque species, aiding survival assessments.
Area of Science:
- Veterinary Medicine
- Primate Research
- Neonatal Survival Rates
Background:
- Neonatal mortality presents a significant challenge in primate breeding programs.
- Understanding perinatal and neonatal death causes is crucial for improving infant survival.
Purpose of the Study:
- To analyze neonatal mortality in simians at a primate research center.
- To identify risk factors for neonatal death, particularly perinatal mortality.
- To establish criteria for assessing neonatal immaturity and survival risk based on birth weight.
Main Methods:
- Retrospective analysis of 225 simian births over 21 months.
- Categorization of deaths into perinatal (0-7 days) and neonatal (0-30 days) periods.
- Examination of weight-specific death rates in four macaque species to define high and low survival risk groups.
Main Results:
- Overall neonatal mortality was 37% (84 of 225 infants).
- Perinatal mortality accounted for a substantial portion of neonatal deaths (62 of 84).
- Weight-specific death rates differentiated high- and low-risk infant groups in macaques.
Conclusions:
- Neonatal and perinatal mortality rates in simians require attention.
- Birth weight can serve as an indicator for neonatal immaturity and survival risk.
- Further research into species-specific birth weight criteria can enhance neonatal care and survival strategies.
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