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Related Concept Videos

Drug Dosing: Geriatric Patients01:15

Drug Dosing: Geriatric Patients

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Elderly individuals encompass a diverse population with varying degrees of age-related physiological changes. Defining the elderly presents challenges, as the geriatric population is often arbitrarily categorized as individuals older than 65. However, many individuals in this group lead active and healthy lives, with an increasing number surpassing 85 years and falling into the older elderly category. Physiological changes associated with aging impact performance capacity and homeostatic...
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Pharmacodynamics in Geriatric Patients: Effects of Age01:27

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Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
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Drug distribution in the human body is influenced by several factors, including plasma protein concentration, body composition, blood flow, tissue-protein concentration, and tissue fluid pH. Among these, changes in plasma protein concentration and body composition due to aging significantly affect how drugs are distributed within the body. Specifically, aging is associated with a decrease in albumin levels by about 10% and an increase in α1-acid glycoprotein levels. These alterations are...
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Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism01:18

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Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
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Related Experiment Video

Updated: Feb 9, 2026

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Lessons Learned From a Multisite Evaluation of Geriatric and Extended Care Programs.

Omonyêlé L Adjognon1, Jennifer L Sullivan1,2, Ann Hendricks1,2

  • 11 VA Boston Health Care System, Boston, MA, USA.

Health Promotion Practice
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Summary

This study shares lessons from a large-scale geriatric care program evaluation. It identifies factors influencing multisite implementation studies to improve future health program evaluations.

Keywords:
health promotionprogram planning and evaluationquality assurance/quality improvement

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Area of Science:

  • Health Services Research
  • Program Evaluation
  • Public Health

Background:

  • Multisite evaluation and implementation studies are increasingly common in healthcare.
  • Evaluating large-scale, multiyear programs presents unique challenges.
  • Geriatric and extended care programs often involve diverse implementation models.

Purpose of the Study:

  • To reflect on lessons learned from a specific large-scale, multiyear geriatric and extended care program evaluation.
  • To identify facilitators and barriers in multisite evaluation of programs with varied implementation models.
  • To enhance the quality of large-scale health program implementation evaluations.

Main Methods:

  • Conducting multiple rounds of data collection.
  • Performing iterative analyses.
  • Generating comprehensive reports.

Main Results:

  • Key factors influencing the success or challenges of multisite evaluations were identified.
  • Practical insights were gained from managing complex data collection and analysis across multiple sites.
  • The evaluation process highlighted the importance of adapting strategies to different program implementation models.

Conclusions:

  • Knowledge from this complex evaluation can inform funders, implementers, and staff involved in public health programs.
  • Improved planning and engagement in complex evaluations can lead to better health outcomes in diverse settings.
  • Sharing lessons learned can enhance the effectiveness of future large-scale health program implementation studies.