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Supervised Machine Learning for Semi-Quantification of Extracellular DNA in Glomerulonephritis
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C3 glomerulonephritis associated with monoclonal gammopathy of renal significance: case report

Juana Alonso-Titos1, Lara Perea-Ortega1, Eugenia Sola1

  • 1Nephrology Department, Carlos Haya Regional University Hospital, University of Malaga, IBIMA, REDinREN (RD16/0009/0006), Avda. Carlos Haya s/n, E-29010, Malaga, Spain.

BMC Nephrology
|June 10, 2018
PubMed

Insights

Monoclonal gammopathy of renal significance (MGRS) involves kidney damage and systemic issues. Early diagnosis and chemotherapy are crucial for managing this condition and preserving renal function.

Area of Science:

  • Nephrology
  • Immunology
  • Pathology

Background:

  • Monoclonal gammopathy of renal significance (MGRS) presents significant morbidity due to severe renal lesions and systemic complications.
  • Early diagnosis and targeted chemotherapy to inhibit immunoglobulin production are essential for managing MGRS.

Observation:

  • A 75-year-old male with chronic kidney disease experienced rapid renal function decline.
  • Kidney biopsy revealed C3 glomerulonephritis with exclusive C3 deposits and a membranoproliferative pattern.
  • Skin biopsy demonstrated endothelial complement deposition, supporting MGRS diagnosis.

Findings:

  • The patient's condition was attributed to the alternative complement pathway activation by an anomalous immunoglobulin.
  • Despite treatment with plasmapheresis, bortezomib, and steroids, advanced chronic kidney disease progressed.

Implications:

  • Monoclonal gammopathy should be considered in adult patients presenting with membranoproliferative glomerulonephritis.
  • This case highlights the complex interplay between monoclonal proteins, complement activation, and renal pathology in MGRS.
Abstract

Keywords:
Alternative complement pathwayC3 glomerulonephritisCase reportChronic kidney diseaseMonoclonal gammopathy

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