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A Single-Cell Transcriptomic Atlas of Thymus Organogenesis Resolves Cell Types and Developmental Maturation

Eric M Kernfeld1, Ryan M J Genga1, Kashfia Neherin1

  • 1Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Medical School, Worcester, MA 01605, USA.

Immunity
|June 10, 2018
PubMed
Summary

This study maps thymus development at single-cell resolution, revealing immune cell dynamics and epithelial maturation. It implicates embryonic thymus cells in autoimmune disease origins, providing a key resource for immunology research.

Keywords:
Drop-seqcell atlasdevelopmentlymphocyteslymphoid organsingle-cell RNA-seqthymic epitheliumthymusthymus organogenesistranscriptomics

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