Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Complement System01:27

Complement System

10.8K
The complement system is a group of approximately 20 plasma proteins that strengthen the body's defenses against infections through opsonization, inflammation, and cell lysis. Opsonization involves coating pathogens with complement proteins, making them more recognizable and facilitating phagocyte engulfment. Certain complement proteins induce inflammation that attracts immune cells to the site of infection. Cell lysis involves the destruction of pathogens through the formation of a...
10.8K
Complementation Tests00:49

Complementation Tests

6.3K
A complementation test is a simple cross to identify whether the two mutations are located on the same gene or different genes. It was first performed by Edward Lewis in the 1940s while working on fruit flies. He developed the test to identify the location and arrangement of different mutations on chromosomes.
Organisms heterozygous for different mutations are crossed pairwise in all combinations. If present on different genes, the mutations can complement each other by providing the missing...
6.3K
C4 Pathway and CAM01:27

C4 Pathway and CAM

49.3K
Most plants use the C3 pathway for carbon fixation. However, some plants, such as sugar cane, corn, and cacti that grow in hot conditions, use alternative pathways to fix carbon and conserve energy loss due to photorespiration. Photorespiration is the process that occurs when the oxygen concentration is high. Under such conditions, the rubisco enzyme in the Calvin cycle binds O2 instead of CO2, which halts photosynthesis and consumes energy.
C4 Pathway
The C4 pathway is used by plants such as...
49.3K
Other Glycolytic Pathways01:24

Other Glycolytic Pathways

941
The pentose phosphate pathway (PPP) operates in parallel with glycolysis, facilitating the metabolism of both pentoses and glucose. This pathway consists of two distinct phases: the oxidative and non-oxidative phases. While it does not directly generate ATP, the intermediates formed during the process can integrate into glycolysis, contributing to cellular energy metabolism when required.Oxidative Phase: NADPH ProductionThe oxidative phase of the pentose phosphate pathway is primarily...
941
Auditory Pathway01:15

Auditory Pathway

7.4K
Auditory pathways constitute the complex neural circuits responsible for transmitting and interpreting auditory information from the peripheral auditory system to the brain. Sound waves are initially captured by the outer ear, funneled through the ear canal, and reach the tympanic membrane (eardrum). These vibrations are transmitted via the middle ear's ossicles to the inner ear's cochlea.
When viewed cross-sectionally, the cochlea reveals the scala vestibuli and scala tympani flanking...
7.4K
ER Retrieval Pathway01:45

ER Retrieval Pathway

4.8K
In the secretory pathway, vesicles transport proteins from one cellular compartment to another in forward transport to deliver the protein to its correct location. Occasionally, misfolded proteins and incorrect proteins escape their original compartments, and a retrieval pathway is used to return the escaped proteins to their original compartment.
The ER uses many checkpoints to prevent the entry of incorrectly folded or a resident protein as cargo onto a transport vesicle. These mechanisms...
4.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Applying participatory systems approaches to enhance child mental health in local communities in Denmark: a process evaluation.

Health research policy and systems·2026
Same author

Highlighting individual patient data related to chimeric antigen receptor T-cell therapy in refractory autoimmune rheumatic diseases.

Scandinavian journal of rheumatology·2025
Same author

Sleep Position Detection for Closed-Loop Treatment of Sleep-Related Breathing Disorders.

IEEE ... International Conference on Rehabilitation Robotics : [proceedings]·2022
Same author

Electrolyte profiles with induced hypothermia: A sub study of a clinical trial evaluating the duration of hypothermia after cardiac arrest.

Acta anaesthesiologica Scandinavica·2022
Same author

Increased synovial galectin-3 induce inflammatory fibroblast activation and osteoclastogenesis in patients with rheumatoid arthritis.

Scandinavian journal of rheumatology·2022
Same author

Association between severe diabetic retinopathy and lectin pathway proteins - an 18-year follow-up study with newly diagnosed type 1 diabetes patients.

Immunobiology·2020
Same journal

Recent Thymic Emigrant Levels in Inborn Errors of Immunity: Is Their Diagnostic Value Greater Than We Think?

Scandinavian journal of immunology·2026
Same journal

The EBNA-1 Conundrum: Does Epstein-Barr Virus Invoke Autoimmune Pathology in a Population Subset by Poorly Purine-Loading Its Major Latency-Maintaining Transcript?

Scandinavian journal of immunology·2026
Same journal

Unsupervised Flow Cytometry Reveals a Constant Shift Towards Activated CD4<sup>+</sup> T Cell Subsets in APECED.

Scandinavian journal of immunology·2026
Same journal

RETRACTION: Interleukin-13 Induces T Helper Type 2 Immune Responses in OVA-Immunized BALB/c Mice Bearing a T Cell Lymphoma.

Scandinavian journal of immunology·2026
Same journal

Development of a Detection Method for Soluble Urokinase-Type Plasminogen Activator Receptor and Its Application in Predicting Prognosis of Severe COVID-19.

Scandinavian journal of immunology·2026
Same journal

Crohn's Disease Enteritis: Pathophysiological Mechanisms and Therapeutic Approaches.

Scandinavian journal of immunology·2026
See all related articles

Related Experiment Video

Updated: Feb 9, 2026

Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury
10:25

Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury

Published on: August 30, 2011

18.7K

The complement lectin pathway after cardiac arrest.

S F Haugaard1, A N Jeppesen2, A Troldborg3

  • 1Department of Clinical Biochemistry, Centre for Hemophilia and Thrombosis, Aarhus University Hospital, Aarhus, Denmark.

Scandinavian Journal of Immunology
|June 10, 2018
PubMed
Summary
This summary is machine-generated.

The lectin pathway (LP) proteins were altered in cardiac arrest patients compared to healthy individuals. However, LP protein levels were not linked to targeted temperature management duration or 30-day survival rates.

Keywords:
complementhumaninflammationmoleculesprocessessubject

More Related Videos

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
10:55

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

Published on: January 13, 2023

2.3K
Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest
07:02

Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest

Published on: January 5, 2018

12.6K

Related Experiment Videos

Last Updated: Feb 9, 2026

Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury
10:25

Normothermic Cardiac Arrest and Cardiopulmonary Resuscitation: A Mouse Model of Ischemia-Reperfusion Injury

Published on: August 30, 2011

18.7K
A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation
10:55

A Piglet Perinatal Asphyxia Model to Study Cardiac Injury and Hemodynamics after Cardiac Arrest, Resuscitation, and the Return of Spontaneous Circulation

Published on: January 13, 2023

2.3K
Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest
07:02

Utilizing the Modified T-Maze to Assess Functional Memory Outcomes After Cardiac Arrest

Published on: January 5, 2018

12.6K

Area of Science:

  • Immunology
  • Complement System Biology

Background:

  • The lectin pathway (LP) is implicated in inflammatory responses.
  • Investigating LP protein levels in cardiac arrest (CA) is crucial for understanding post-resuscitation pathophysiology.

Purpose of the Study:

  • To measure LP protein levels in out-of-hospital cardiac arrest (OHCA) patients.
  • To compare OHCA patient LP levels with healthy controls.
  • To assess the impact of targeted temperature management (TTM) duration on LP levels and their association with 30-day mortality.

Main Methods:

  • Quantified levels of mannan-binding lectin (MBL), M-ficolin, H-ficolin, collectin liver 1 (CL-L1), MBL-associated serine proteases (MASP-1, MASP-2, MASP-3), and MBL-associated protein of 44 kDa (MAp44) using time-resolved immunofluorometric assays.
  • Included 82 OHCA patients randomized to 24 or 48 hours of TTM at 33°C.
  • Compared patient data with 82 healthy individuals.

Main Results:

  • Significantly higher levels of CL-L1, MASP-1, MASP-2, and MAp44, and lower levels of M-ficolin were observed in OHCA patients versus healthy controls.
  • MASP-2, MASP-3, and M-ficolin levels showed significant changes between 24 and 48 hours of TTM.
  • No significant differences in LP protein levels were found between 30-day survivors and non-survivors.

Conclusions:

  • Cardiac arrest patients exhibit altered lectin pathway protein levels, suggesting potential LP activation.
  • The duration of targeted temperature management did not influence LP protein levels.
  • Lectin pathway protein levels were not associated with 30-day mortality following cardiac arrest.