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Aline de Souza1, Débora Soares Souza Marins1, Samir Leite Mathias2

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International Journal of Pharmaceutics
|June 11, 2018
PubMed
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Leishmaniases, affecting millions globally, face treatment challenges due to drug toxicity and resistance. Nanotechnology offers a promising solution by improving drug delivery for better efficacy and reduced side effects in treating leishmaniasis.

Keywords:
Drug delivery systemsDrug targetingHuman leishmaniasisNanotechnologyNanotherapeuticsTreatment

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Area of Science:

  • Parasitology
  • Infectious Diseases
  • Nanomedicine

Background:

  • Leishmaniases are significant global health concerns caused by protozoan parasites, with millions infected and at risk, particularly in developing countries.
  • Current chemotherapy for leishmaniasis suffers from limited effective drugs, toxicity, long treatment durations, and the emergence of drug-resistant strains, impacting patient compliance.
  • Brazil faces a substantial burden of both visceral leishmaniasis (VL) and cutaneous leishmaniasis (CL).

Purpose of the Study:

  • To comprehensively review recent advancements in nanotechnology for treating leishmaniases.
  • To highlight the potential of nano drug delivery systems (NanoDDS) in improving antileishmanial therapy.
  • To underscore the importance of nanotechnology in addressing the challenges of leishmaniasis treatment.

Main Methods:

  • This review synthesizes findings from recent scientific literature on nanotechnology applications in leishmaniasis treatment.
  • It focuses on studies investigating nano drug delivery systems (NanoDDS) for antileishmanial agents.
  • The compilation examines strategies for intracellular drug localization and efficacy enhancement.

Main Results:

  • NanoDDS can effectively target antileishmanial drugs to intracellular sites within macrophages in organs like the liver, spleen, and bone marrow.
  • Nanotechnology-based approaches show potential for enhancing the therapeutic efficacy of antileishmanial drugs.
  • These systems can significantly reduce the toxic effects associated with conventional antileishmanial chemotherapy.

Conclusions:

  • Nanotechnology presents a powerful strategy to overcome the limitations of current leishmaniasis treatments.
  • Nano drug delivery systems offer improved efficacy and reduced toxicity, enhancing patient compliance and combating drug resistance.
  • Further research and application of nanotechnology are crucial for advancing the management of leishmaniases worldwide.