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Updated: Feb 9, 2026

Urethral Stricture Induction Followed by Buccal Mucosa Graft Urethroplasty in a Rat Model
Published on: April 28, 2023
[Causes and management for male urethral stricture]
Caifang Chen1, Mingqiang Zeng2, Ruizhi Xue3
1Department of Geriatric Medicine, Xiangya Hospital, Central South University, Changsha 410008, China.
Male urethral stricture etiology is shifting towards trauma and iatrogenic causes. Treatment is evolving from endoscopic procedures to urethroplasty for better outcomes.
Area of Science:
- Urology
- Surgical Research
- Male Reproductive Health
Background:
- Male urethral stricture is a significant cause of lower urinary tract symptoms.
- Understanding evolving etiologies and treatment outcomes is crucial for patient management.
Purpose of the Study:
- To investigate the changing causes of male urethral stricture.
- To analyze current therapeutic strategies and their associated complications.
- To review complex cases and treatment shifts.
Main Methods:
- Retrospective analysis of 183 male urethral stricture patients.
- Data collected on etiology, stricture location, length, treatment, and complications.
- Statistical comparison of treatment outcomes and complication rates.
Main Results:
- Traumatic (52.4%) and iatrogenic (29.5%) injuries are leading causes of urethral stricture.
- Posterior (45.9%) and anterior (44.8%) urethral strictures are most common.
- Urethroplasty (54.1%) is now preferred over endoscopic surgery (21.9%).
- Older patients (>65) showed higher complication rates with transurethral resection of the prostate (TURP).
Conclusions:
- Male urethral stricture etiology is increasingly linked to trauma and iatrogenic factors.
- Treatment paradigms have shifted towards urethroplasty from endoscopic interventions.
- Age influences complication risks, particularly with TURP in elderly patients.
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