Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Animal Mitochondrial Genetics02:59

Animal Mitochondrial Genetics

9.3K
Among all the organelles in an animal cell, only mitochondria have their own independent genomes. Animal mitochondrial DNA is a double-stranded, closed-circular molecule with around 20,000 base pairs. Mitochondrial DNA is unique in that one of its two strands, the heavy, or H, -strand is guanine rich, whereas the complementary strand is cytosine rich and called the light, or L, -strand. Compared to nuclear DNA, mitochondrial DNA has a very low percentage of non-coding regions and is marked by...
9.3K
Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes02:16

Comparing Mitochondrial, Chloroplast, and Prokaryotic Genomes

16.5K
The present-day mitochondrial and chloroplast genomes have retained some of the characteristics of their ancestral prokaryotes and also have acquired new attributes during their evolution within eukaryotic cells. Like prokaryotic genomes, mitochondrial and chloroplast genomes neither bind with histone-like proteins nor show complex packaging into chromosome-like structures, as observed in eukaryotes. Unlike mitotic cell divisions observed in eukaryotic cells, mitochondria and chloroplasts...
16.5K
Export of Mitochondrial and Chloroplast Genes02:19

Export of Mitochondrial and Chloroplast Genes

4.2K
A eukaryotic cell can have up to three different types of genetic systems: nuclear, mitochondrial, and chloroplast. During evolution, organelles have exported many genes to the nucleus; this transfer is still ongoing in some plant species. Approximately 18% of the Arabidopsis thaliana nuclear genome is thought to be derived from the chloroplast’s cyanobacterial ancestor, and around 75% of the yeast genome derived from the mitochondria’s bacterial ancestor. This export has occurred...
4.2K
The Inner Mitochondrial Membrane01:28

The Inner Mitochondrial Membrane

4.7K
The inner mitochondrial membrane is the primary site of ATP synthesis. The inner membrane domain that forms a smooth layer adjacent to the outer membrane is called the inner boundary membrane. This domain contains membrane transporters that drive metabolites in and out of the mitochondria.  In contrast, the inner membrane network that invaginates into the matrix space is called the cristae membrane. This domain accounts for principle mitochondrial function as it accommodates the protein...
4.7K
Mitochondrial Membranes01:45

Mitochondrial Membranes

17.2K
A single mitochondrion is a bean-shaped organelle enclosed by a double-membrane system. The outer membrane of mitochondria is smooth and contains many porins - the integral membrane transporters. Porins enable free diffusion of ions and small uncharged molecules through the outer mitochondrial membrane but limit the transport of molecules larger than 5000 Daltons. Further, the outer mitochondrial membrane forms a unique structure called membrane contact sites with other subcellular organelles,...
17.2K
Mitochondrial Protein Sorting01:39

Mitochondrial Protein Sorting

5.8K
Mitochondria are double-membrane organelles of the eukaryotes involved in cellular metabolism, signaling, ATP synthesis, and programmed cell death.  Each of these processes requires specific proteins and enzymes that must be correctly sorted to the right mitochondrial subcompartment for the proper functioning of the organelle.
Most of these mitochondrial proteins are encoded by the nucleus and imported to the mitochondria as unfolded or loosely folded precursors. Mitochondrial precursors...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fatty acid synthesis therapy-induced senescence (FASTIS) in cancer cells.

Cell death & disease·2026
Same author

Epigenetic Clocks in the Cosmic Silence of a Deep Underground Laboratory: Implications for Aging and Space Exploration.

Aging and disease·2026
Same author

Cellular Senescence in the Absence of Galactic Cosmic-Ray Muons.

Aging and disease·2026
Same author

Characterising Epigenetic Tipping Points using a Spectral Dimension Reduction Approach.

Bulletin of mathematical biology·2026
Same author

Mitochondrial bioenergetics-SASP crosstalk determines senolytic efficacy in therapy-induced senescence.

Cell death discovery·2026
Same author

Multiscale modelling shows how cell-ECM interactions impact ECM fibre alignment and cell detachment.

PLoS computational biology·2025

Related Experiment Video

Updated: Feb 9, 2026

Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells
12:42

Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells

Published on: June 17, 2008

14.7K

Mitostemness.

Elisabet Cuyàs1,2, Sara Verdura1,2, Núria Folguera-Blasco3

  • 1a Program Against Cancer Therapeutic Resistance (ProCURE), Metabolism and Cancer Group , Catalan Institute of Oncology , Girona , Spain.

Cell Cycle (Georgetown, Tex.)
|June 12, 2018
PubMed
Summary
This summary is machine-generated.

Mitochondria drive cancer stem cell (CSC) traits through "mitostemness." Targeting these mitochondrial functions offers a new therapeutic strategy to eliminate cancer by exploiting their bacterial origins.

Keywords:
Cancer stem cellsmetabolismmitochondria

More Related Videos

Improving the Accuracy of Flow Cytometric Assessment of Mitochondrial Membrane Potential in Hematopoietic Stem and Progenitor Cells Through the Inhibition of Efflux Pumps
07:17

Improving the Accuracy of Flow Cytometric Assessment of Mitochondrial Membrane Potential in Hematopoietic Stem and Progenitor Cells Through the Inhibition of Efflux Pumps

Published on: July 30, 2019

8.4K
Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
07:57

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Published on: December 26, 2019

13.0K

Related Experiment Videos

Last Updated: Feb 9, 2026

Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells
12:42

Probing for Mitochondrial Complex Activity in Human Embryonic Stem Cells

Published on: June 17, 2008

14.7K
Improving the Accuracy of Flow Cytometric Assessment of Mitochondrial Membrane Potential in Hematopoietic Stem and Progenitor Cells Through the Inhibition of Efflux Pumps
07:17

Improving the Accuracy of Flow Cytometric Assessment of Mitochondrial Membrane Potential in Hematopoietic Stem and Progenitor Cells Through the Inhibition of Efflux Pumps

Published on: July 30, 2019

8.4K
Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry
07:57

Measurement of Mitochondrial Mass and Membrane Potential in Hematopoietic Stem Cells and T-cells by Flow Cytometry

Published on: December 26, 2019

13.0K

Area of Science:

  • Oncology
  • Cell Biology
  • Mitochondrial Biology

Background:

  • Cancer stem cells (CSCs) are crucial for tumor growth and resistance.
  • Mitochondria play a significant role in CSC self-renewal and differentiation resistance.
  • Understanding CSC regulation is vital for developing effective cancer therapies.

Purpose of the Study:

  • Introduce the concept of "mitostemness" to describe mitochondria-dependent signaling in CSCs.
  • Highlight the therapeutic potential of targeting mitostemness traits.
  • Review pre-clinical evidence and discuss clinical translation strategies for mitostemness-targeting drugs.

Main Methods:

  • Literature review of pre-clinical studies on compounds targeting mitostemness.
  • Analysis of mitochondrial functions (mitonuclear communication, mitoproteome, fission/fusion) in CSCs.
  • Discussion of therapeutic strategies and clinical translation pathways.

Main Results:

  • Mitostemness, rooted in mitochondria's bacterial origin, governs CSC self-renewal and resistance.
  • Key mitostemness traits include mitonuclear communication, mitoproteome, and mitochondrial dynamics.
  • Pre-clinical data show investigational compounds can modulate these traits.

Conclusions:

  • Targeting mitostemness offers a novel therapeutic dimension against CSCs.
  • Exploiting mitochondria's biochemical, biophysical, and morpho-physiological features can improve cancer treatment.
  • Further research and clinical translation of mitostemness drugs are warranted.