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Updated: Feb 9, 2026

Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism
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Quantification of Global Diastolic Function by Kinematic Modeling-based Analysis of Transmitral Flow via the Parametrized Diastolic Filling Formalism

Published on: September 1, 2014

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Early diastolic dysfunction and respiratory morbidity in premature infants: an observational study

Neidin Bussmann1,2, Colm Breatnach1,2, Philip T Levy3

  • 1Department of Neonatology, The Rotunda Hospital, Dublin, Ireland.

Journal of Perinatology : Official Journal of the California Perinatal Association
|June 12, 2018
PubMed

Insights

Diastolic dysfunction in preterm infants on day one is linked to increased need for invasive ventilation. This finding highlights early cardiac assessment importance for neonatal respiratory support decisions.

Area of Science:

  • Neonatal Cardiology
  • Pediatric Critical Care
  • Echocardiography

Background:

  • Preterm infants face significant respiratory challenges, often requiring respiratory support.
  • Assessing cardiac function early in neonates is crucial for predicting respiratory outcomes.
  • Diastolic dysfunction is a potential indicator of cardiac compromise in newborns.

Purpose of the Study:

  • To determine if left ventricular diastolic dysfunction, measured within the first 12 hours of life, predicts the need for invasive ventilation in preterm infants.
  • To investigate the association between early echocardiographic measures of diastolic function and the requirement for mechanical ventilation.

Main Methods:

  • Retrospective observational study involving preterm infants (<32 weeks gestation).
  • Tissue Doppler echocardiography performed within the first 12 hours of life.
  • Comparison of diastolic function parameters between invasively ventilated infants and those on continuous positive airway pressure (CPAP).

Main Results:

  • Invasively ventilated infants (n=96) showed significantly lower left ventricular (LV) e' and LV ea' ratios compared to CPAP-supported infants.
  • These differences persisted after adjusting for common neonatal confounders.
  • LV e' adjusted odds ratio (OR) was 0.62 (95% CI 0.45-0.87, p<0.01) and LV ea' adjusted OR was 0.14 (95% CI 0.03-0.68, p=0.01).

Conclusions:

  • Left ventricular diastolic dysfunction identified on day one of life is an independent predictor of increased risk for requiring invasive ventilation in preterm infants.
  • Early echocardiographic assessment of diastolic function may aid in identifying neonates at high risk for respiratory failure.
Abstract

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