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Updated: Feb 9, 2026

Synthesis and Microdiffraction at Extreme Pressures and Temperatures
Published on: October 7, 2013
LOW-GWP REFRIGERANTS FOR MEDIUM AND HIGH-PRESSURE APPLICATIONS
Piotr A Domanski1, Riccardo Brignoli1, J Steven Brown2
1Energy and Environment Division, National Institute of Standards and Technology Gaithersburg, MD 20899, USA.
Finding suitable low-global warming potential (GWP) refrigerants is challenging. Many options have trade-offs in efficiency, safety (flammability), and capacity, limiting ideal replacements for air-conditioning and refrigeration.
Area of Science:
- Thermodynamics and Fluid Dynamics
- Environmental Science
- Chemical Engineering
Background:
- Refrigerant selection requires balancing environmental impact (Global Warming Potential - GWP), safety, and performance.
- Previous research screened refrigerants based on thermodynamic properties.
Purpose of the Study:
- To evaluate the performance of low-GWP refrigerant alternatives for small and medium-sized cooling and heating systems.
- To assess the limitations of current low-GWP refrigerant options.
Main Methods:
- Screening a refrigerant database using environmental, chemical, and physical attributes.
- Utilizing cycle calculations based on thermodynamic properties.
- Employing a simulation model with transport properties and optimized heat exchangers for detailed performance assessment.
Main Results:
- Low-GWP refrigerant options are scarce, especially those matching the volumetric capacity of R 410A or R-404A.
- Identified low-GWP fluids with good Coefficient of Performance (COP) exhibit mild flammability.
- Refrigerant blends offer flexibility in balancing COP, capacity, flammability, and GWP.
Conclusions:
- The search for ideal, high-performing, low-GWP refrigerants with minimal drawbacks is unlikely.
- Detailed modeling is crucial for accurately assessing refrigerant performance in systems with forced-convection heat transfer.
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