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A Syngeneic Orthotopic Osteosarcoma Sprague Dawley Rat Model with Amputation to Control Metastasis Rate
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Limb Salvage Versus Amputation in Conventional Appendicular Osteosarcoma: a Systematic Review
Julio J Jauregui1, Vidushan Nadarajah1,2, Joseph Munn3
11Department of Orthopaedics, University of Maryland Medical Center, 110 S. Paca Street, 6th Floor, Suite 300, Baltimore, MD 21201 USA.
Indian Journal of Surgical Oncology
|June 12, 2018
Summary
For appendicular osteosarcoma, limb salvage and amputation offer similar survival rates. Limb salvage has higher complication and recurrence risks but better cosmetic outcomes, supporting its use when functional limbs are achievable.
Area of Science:
- Orthopedic Oncology
- Surgical Oncology
- Cancer Research
Background:
- Appendicular osteosarcoma survivorship has improved.
- Debate persists regarding amputation versus limb salvage procedures.
Purpose of the Study:
- To systematically review and compare outcomes of limb salvage versus amputation for appendicular osteosarcoma.
Main Methods:
- Systematic literature review across three peer-reviewed databases.
- Evaluation of studies comparing limb salvage and amputation outcomes.
Main Results:
- Similar 5-year survivorship (62% salvage vs. 58% amputation).
- Higher local recurrence (8.2% vs. 3.0%) and complication rates (52% vs. 34%) with limb salvage.
- Comparable metastasis rates (33% vs. 38%).
Conclusions:
- Limb salvage and amputation show comparable survival for appendicular osteosarcoma.
- Limb salvage offers better cosmesis but carries higher risks of recurrence and complications.
- Limb salvage is supported when wide margins and functional limb retention are possible.
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