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Skull base osteomyelitis secondary to Scedosporium apiospermum infection

Martin Doss1, David Doss2

  • 1Campbelltown Hospital, Therry Road, Campbelltown, Sydney, NSW 2560, Australia.

Radiology Case Reports
|June 12, 2018
PubMed

Insights

Scedosporium apiospermum infections can cause severe complications like skull base osteomyelitis and stroke, particularly in immunocompromised individuals. Early diagnosis and antifungal treatment are crucial for patient survival in these challenging cases.

Area of Science:

  • Mycology
  • Infectious Diseases
  • Radiology

Background:

  • Scedosporium apiospermum is an environmental mold increasingly recognized as a human pathogen.
  • Infections typically affect immunocompromised patients, presenting diverse clinical manifestations.

Observation:

  • A rare case of malignant otitis externa caused by Scedosporium apiospermum is detailed.
  • The infection complicated to include skull base osteomyelitis, internal carotid artery vasculitis, and stroke.

Findings:

  • Prompt diagnosis and targeted antifungal therapy were critical for patient survival.
  • Multimodality imaging played a key role in diagnosing the extensive skull base osteomyelitis and its sequelae.
  • Radiological findings associated with skull base osteomyelitis and its complications were highlighted.

Implications:

  • This case underscores the aggressive potential of Scedosporium apiospermum infections.
  • Highlights the importance of early recognition and aggressive management in complex fungal infections.
  • Emphasizes the utility of advanced imaging in managing invasive fungal infections of the skull base.
Keywords:
Fungal infectionMalignant otitis externaMycotic aneurysmScedosporium apiospermumSkull base osteomyelitis

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