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Sulforaphane Augments Glutathione and Influences Brain Metabolites in Human Subjects: A Clinical Pilot Study

Thomas W Sedlak1, Leslie G Nucifora1, Minori Koga1

  • 1Department of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.

Molecular Neuropsychiatry
|June 12, 2018
PubMed

Insights

This study shows sulforaphane increases blood and brain glutathione (GSH) levels. This suggests sulforaphane may help address oxidative stress in neuropsychiatric disorders.

Area of Science:

  • Neuroscience
  • Biochemistry
  • Clinical Research

Background:

  • Oxidative stress and reduced glutathione (GSH) are implicated in neuropsychiatric disorders.
  • Peripheral GSH is explored as a biomarker for brain oxidative stress.
  • Preclinical models show correlation between brain and peripheral GSH.

Purpose of the Study:

  • To investigate sulforaphane's effect on blood and brain GSH levels in humans.
  • To explore the relationship between peripheral and brain GSH.
  • To assess sulforaphane as a potential intervention for neuropsychiatric disorders.

Main Methods:

  • A 7-day oral administration of sulforaphane in healthy human subjects.
  • Measurement of blood GSH levels.
  • 7-Tesla magnetic resonance spectroscopy to measure brain GSH in specific regions (anterior cingulate cortex, hippocampus, thalamus).

Main Results:

  • Sulforaphane significantly increased blood GSH levels.
  • A positive correlation was observed between blood and thalamic GSH levels post-treatment.
  • Consistent increases in brain GSH levels were detected following sulforaphane administration.

Conclusions:

  • Sulforaphane effectively increases both peripheral and brain glutathione levels.
  • Peripheral GSH may serve as a reliable indicator of brain GSH status.
  • Sulforaphane shows promise as a potential therapeutic agent for conditions involving oxidative stress.
Keywords:
GlutathioneOxidative stressSulforaphane

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