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Updated: Feb 9, 2026

A Bright NIR-II Fluorescence Probe for Vascular and Tumor Imaging
Published on: March 17, 2023
Probing heterogeneity of NIR induced secondary fluorescence from DNA-stabilized silver nanoclusters at the single
Stefan Krause1, Miguel R Carro-Temboury, Cecilia Cerretani
1Nanoscience Center and Department of Chemistry, University of Copenhagen, Universitetsparken 5, 2100 Copenhagen, Denmark. stefan.krause@chem.ku.dk tom@chem.ku.dk.
Abstract:
In this communication, we investigate optically activated delayed fluorescence (OADF) from DNA-stabilized silver nanoclusters (DNA-AgNCs) at the single molecule level, and we probe the heterogeneity in the primary fluorescence (PF) intensity, NIR induced secondary fluorescence (SF) intensity and SF/PF ratio. Our experiments reveal a heterogeneous distribution in the SF/PF ratio, indicating that engineering of DNA-AgNCs towards a high SF/PF ratio and high OADF signal for background-free imaging might be possible.
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