Related Experiment Videos
Ketanserin does not prevent ACTH-induced hypertension in sheep
Clinical and Experimental Pharmacology & Physiology
|March 1, 1985
Abstract:
The role of serotonin (5HT) in the pathogenesis of ACTH-induced hypertension in sheep has been examined. The pressor responses to injections of 5HT (0.1-30 micrograms/kg) were similar in normotensive and hypertensive sheep. Prior treatment with the 5HT2 receptor antagonist ketanserin had no effect on the development of hypertension produced by ACTH administration.