Related Experiment Video
Updated: Feb 9, 2026

Determination of DNA Methylation of Imprinted Genes in Arabidopsis Endosperm
Published on: January 28, 2011
The effect of inflammation-related lifestyle exposures and interactions with gene variants on long interspersed
Priyanka Gogna1, Dylan E O'Sullivan1, Will D King1
1Department of Public Health Sciences, Queen's University, Kingston, Ontario, Canada.
Aim:
To examine the relationship between inflammation-related lifestyle factors and long interspersed nuclear element-1 (LINE-1) DNA methylation, and test for interaction by gene variants involved in one-carbon metabolism.
Patients & Methods:
The study population consisted of 280 individuals undergoing colonoscopy screening. Multivariable linear regression was employed to examine associations of physical activity, BMI and NSAID use with LINE-1 DNA methylation and interactions with MTR and MTHFR gene variants.
Results:
The highest quartile of physical activity compared with the lowest was associated with higher LINE-1 DNA methylation (p = 0.005). Long-term NSAID use and a normal BMI were associated with increased LINE-1 DNA methylation among individuals with the variant MTR allele (p = 0.02; p = 0.03).
Conclusion:
This study provides evidence that inflammation-related exposures may influence LINE-1 DNA methylation.
Related Concept Videos
Histone Variants at the Centromere
Nuclear Stability
To hold positively charged protons together...
Non-nuclear Inheritance
Nuclear Fusion
A helium nucleus has a mass that is 0.7% less than that of four hydrogen nuclei; this lost mass is converted into energy during the fusion. This reaction produces about...
Nuclear Transmutation
Radioactivity and Nuclear Equations
A nuclide of an element has a specific number of protons and...

