DIAGNOSTIC VALUE OF THE INTEGRAL HEMATOLOGICAL INDEXES AND CHEMILUMINESCENCE OF NEUTROPHILS IN SEVERE ACUTE...

Research aim is estimation of dependence between integral hematological indexes and chemiluminescence of neutrophils at severe acute pancreatitis.

The 70 patients with acute pancreatitis were examined, severity of disease were reviled based on integral score Ranson, results of clinical and laboratories examinations, diagnosis was confirmed by instrumentals methods of diagnostics. Patients were divided into two clinical groups: 35 patients with no severe acute pancreatitis and 35 patients with severe acute pancreatitis. Integral hematological indexes were calculated based on results of clinical blood test. Functional activity of neutrophils were estimated by chemiluminescence analysis, activator of reaction was luminal.

Severe acute pancreatitis was characterized by lowering of intensity chemiluminescence with prevalence hypoxic type of active oxygen's generation 94,28% patients. High negative correlations between integral indexes of inflammatory reaction and degree of endotoxicosis (Kaif - Kalif's leukocytal index of intoxication, index of correlation between neutrophils and lymphocytes, G.D. Dashnayahtsa nuclear index and reactive response of neutrophils) and indexes of chemiluminescence reaction, which show type of active oxygen's generation (intensity of reaction and peak reaction time) were revealed. It allowed talking about high degree of oxidative stress at expressed inflammatory and necrotic process in pancreatic tissue. Decrease of antioxidant resources against a background expressed pathologic process at severe acute pancreatitis was confirmed by High negative correlations between N index of correlation between neutrophils and square under curve of chemiluminescence reaction (-0,62, p=0,001 at spontaneous reaction and -0,72, p=0,001 activated).