Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

2.0K
Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.0K
Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test01:22

Effect of Hepatic Disease on Pharmacokinetics: Pathophysiologic Assessment and Liver Function Test

207
In clinical practice, the direct measurement of hepatic blood flow to evaluate liver function presents significant challenges due to the intricate and specialized nature of the necessary techniques. Consequently, healthcare professionals often rely on empirical estimates derived from thorough patient examinations and liver function tests to gauge liver health. Among the tools at their disposal, the Child–Pugh and MELD scoring systems stand out for their ability to categorize and assess...
207
Oxidation of Alcohols02:37

Oxidation of Alcohols

16.2K
In this lesson, the oxidation of alcohols is discussed in depth. The various reagents used for oxidation of primary and secondary alcohols are detailed, and their mechanism of action is provided.
The process of oxidation in a chemical reaction is observed in any of the three forms:
16.2K
Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis02:29

Ethers from Alcohols: Alcohol Dehydration and Williamson Ether Synthesis

13.0K
Overview
Ethers can be prepared from organic compounds by various methods. Some of them are discussed below,
Preparation of Ethers by Alcohol Dehydration
In this method, in the presence of protic acids, alcohol dehydrates to produce alkenes and ethers under different conditions. For example, in the presence of sulphuric acid, dehydration of ethanol at 413 K yields ethoxyethane, whereas it yields ethene at 443 K.
13.0K
Protection of Alcohols02:31

Protection of Alcohols

8.1K
This lesson delves into the concept of protection and deprotection of a functional group fundamental to synthetic organic chemistry. These phenomena are explained in the context of aliphatic and aromatic alcohols.
Protection
It defines a protecting group as the masking agent to make the more reactive species inert to a given set of conditions. This concept is depicted via the illustration of liquid flow through different outlets in an assembly of pipes. The analogy helps to understand the role...
8.1K
Overview of Fatty Acid Metabolism01:28

Overview of Fatty Acid Metabolism

37.1K
Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...
37.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Case of multiple systemic (extrahepatic) manifestations of chronic HCV infection (analysis of the literature and own observations). Case report].

Terapevticheskii arkhiv·2023
Same author

[Long-Chain Free Fatty Acids Influence Lipid Accumulation, Lysosome Activation and Glycolytic Shift in Various Cells In Vitro].

Molekuliarnaia biologiia·2021
Same author

[Cardiovascular syphilis (current state of the problem and analysis of own observations)].

Terapevticheskii arkhiv·2020
Same author

[The Experience of Use Triple Antithrombotic Therapy in Patients With Acute Coronary Syndrome and Atrial Fibrillation].

Kardiologiia·2017
Same author

[Clinical and metabolic features of nonalcoholic fatty liver disease in men and women].

Terapevticheskii arkhiv·2017
Same author

[ALLELES C282Y AND H63D HFE GENE, INSULIN RESISTANCE AND SUSCEPTIBILITY TO DISTURBANCE OF PORPHYRIN METABOLISM IN NON-ALCOHOLIC FATTY LIVER DISEASE].

Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology·2015

Related Experiment Video

Updated: Feb 9, 2026

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.8K

NON-ALCOHOLIC FATTY LIVER DISEASE IN ELDERLY.

A B Krivosheev, A D Kuimov, K V Popov

    Eksperimental'Naia I Klinicheskaia Gastroenterologiia = Experimental & Clinical Gastroenterology
    |June 12, 2018
    PubMed
    Summary

    Nonalcoholic fatty liver disease (NAFLD) shows more significant metabolic issues like insulin resistance in younger individuals. Elderly patients with NAFLD often present with comorbid conditions.

    More Related Videos

    Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
    09:27

    Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

    Published on: April 1, 2021

    4.0K
    Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
    08:20

    Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

    Published on: December 2, 2022

    2.3K

    Related Experiment Videos

    Last Updated: Feb 9, 2026

    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
    08:41

    Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

    Published on: March 24, 2023

    1.8K
    Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish
    09:27

    Analysis of Liver Microenvironment During Early Progression of Non-Alcoholic Fatty Liver Disease-Associated Hepatocellular Carcinoma in Zebrafish

    Published on: April 1, 2021

    4.0K
    Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model
    08:20

    Investigating the Protective Effects of Platycodin D on Non-Alcoholic Fatty Liver Disease in a Palmitic Acid-Induced In Vitro Model

    Published on: December 2, 2022

    2.3K

    Area of Science:

    • Hepatology
    • Metabolic Disorders
    • Geriatrics

    Background:

    • Nonalcoholic fatty liver disease (NAFLD) is a growing health concern.
    • Understanding its clinical course and metabolic derangements is crucial, especially across different age groups.

    Purpose of the Study:

    • To investigate the clinical manifestations and metabolic disturbances in elderly patients with NAFLD.
    • To compare these findings with younger NAFLD patients.

    Main Methods:

    • A cohort of 153 NAFLD patients (97 male, 56 female) was studied.
    • Clinical features, liver function, and metabolism (lipid, carbohydrate, porphyrin) were assessed.
    • Insulin resistance was evaluated.

    Main Results:

    • Elderly NAFLD patients frequently exhibited comorbid pathologies.
    • Younger patients showed more pronounced lipid metabolism disturbances and insulin resistance (hyperinsulinemia).
    • Porphyrin metabolism disorders were common, with initial disorders prevalent in younger individuals and later-stage disorders in the elderly.

    Conclusions:

    • Key NAFLD drivers, insulin resistance and dyslipidemia, are more pronounced in younger patients, suggesting NAFLD onset in early life.
    • Comorbidities are a significant feature of NAFLD in the elderly.