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Updated: Feb 9, 2026

A Suppressor Screen for the Characterization of Genetic Links Regulating Chronological Lifespan in Saccharomyces cerevisiae
Published on: September 17, 2020
Links between genetics and immunology: mutations and antigens
Abstract:
Recent advances in cancer immunotherapy by immune checkpoint blockade are emphasizing the importance of Tcell responses to tumors in disease control. In addition, the development of next generation DNA sequencing technologies combined to reverse immunology approaches facilitate the appreciation of the involvement of T cell responses to neoantigens, which result from tumor-specific genomic alterations, in the immune response to tumors. Neoantigens extend the categories of previously characterized tumor antigens and, together with the latter, offer opportunities to target large proportions of tumors by passive and active specific immunotherapy approaches.
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