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Links between genetics and immunology: mutations and antigens
Bulletin De L'Academie Nationale De Medecine
|June 12, 2018
Summary
Cancer immunotherapy using immune checkpoint blockade highlights T-cell responses. Neoantigens from tumor mutations are key targets for new cancer immunotherapies, improving disease control.
Area of Science:
- Oncology
- Immunology
- Genomics
Background:
- Immune checkpoint blockade has advanced cancer immunotherapy.
- T-cell responses are crucial for controlling tumors.
- Tumor-specific genomic alterations generate neoantigens.
Purpose of the Study:
- To highlight the significance of T-cell responses in cancer immunotherapy.
- To discuss the role of neoantigens in anti-tumor immunity.
- To explore immunotherapy strategies targeting neoantigens.
Main Methods:
- Review of recent advances in cancer immunotherapy.
- Integration of next-generation DNA sequencing technologies.
- Application of reverse immunology approaches.
Main Results:
- T-cell responses are critical for disease control in cancer immunotherapy.
- Neoantigens, arising from tumor mutations, are important targets.
- Neoantigens expand the repertoire of tumor antigens.
Conclusions:
- Neoantigens offer new opportunities for cancer immunotherapy.
- Targeting neoantigens can be achieved through passive and active immunotherapy.
- Advances in sequencing and immunology enhance understanding of anti-tumor responses.
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