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Updated: Feb 9, 2026
07:32
Screening and Identification of Small Peptides Targeting Fibroblast Growth Factor Receptor2 using a Phage Display Peptide Library
Published on: September 30, 2019
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In Vivo Translation of Peptide-Targeted Drug Delivery Systems Discovered by Phage Display
Maureen R Newman1, Danielle S W Benoit1
1Center for Musculoskeletal Research, Department of Orthopaedics , University of Rochester Medical Center , Rochester , New York 14642 , United States.
Bioconjugate Chemistry
|June 12, 2018
Summary
Phage display identifies targeting peptides for drug delivery systems, improving treatment for diseases with narrow therapeutic windows. This method enhances drug specificity and reduces systemic side effects.
Area of Science:
- Biotechnology
- Drug Delivery
- Molecular Biology
Background:
- Targeted drug delivery is crucial for therapeutics with narrow therapeutic windows and significant side effects.
- Peptide-ligand interactions are key for directing drugs to specific tissues.
- Phage display is a powerful technique for discovering high-affinity peptide ligands.
Purpose of the Study:
- To review the methodology of phage display for identifying peptide targeting sequences.
- To discuss strategies for functionalizing drug carriers with these peptides.
- To highlight in vivo applications and future potential of phage display in drug delivery.
Main Methods:
- Phage display library screening to identify peptides binding to target receptors.
- Isolation and sequencing of high-binding phage clones.
- Chemical synthesis and modification of identified peptides for drug carrier conjugation.
Main Results:
- Phage display successfully identifies specific peptide sequences with high affinity for target receptors.
- Phage-derived peptides can be effectively incorporated into various drug delivery systems.
- Examples of successful in vivo translation of phage-display derived targeted drug delivery systems exist.
Conclusions:
- Phage display is a versatile tool for developing targeted drug delivery strategies.
- Functionalizing drug carriers with phage-derived peptides can enhance therapeutic efficacy and reduce systemic toxicity.
- Further research into limitations and novel applications will advance phage display in medicine.
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