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A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration

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Postoperative Cognitive Dysfunction and Noncardiac Surgery.

Lisbeth A Evered^1,2, Brendan S Silbert^1,2

¹From the Department of Anaesthesia and Acute Pain Medicine, St Vincent's Hospital, Melbourne, Fitzroy, Victoria, Australia.

Anesthesia and Analgesia

|June 12, 2018

Summary

This summary is machine-generated.

Postoperative cognitive dysfunction (POCD) is a decline in thinking after surgery. This review contextualizes POCD within broader cognitive disorders like dementia, aiding anesthesiologist understanding.

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Area of Science:

Anesthesiology
Geriatric Medicine
Neuroscience

Background:

Postoperative cognitive dysfunction (POCD) is a decline in cognition after surgery.
POCD has historically been studied separately from general cognitive decline in the elderly.
The causes and definitions of POCD have been heterogeneous.

Purpose of the Study:

To place POCD within the broader context of cognitive decline in the general population.
To redefine POCD using geriatric medicine constructs for clearer clinical impact assessment.
To equip anesthesiologists to manage patients with cognitive impairment undergoing surgery.

Main Methods:

This is a narrative review.
The review synthesizes existing literature on POCD and general cognitive decline.
It examines the redefinition of POCD in relation to geriatric medicine classifications.

Main Results:

Increasing age, baseline cognitive impairment, and lower education levels are associated with POCD.
Redefining POCD using geriatric constructs allows for better elucidation of clinical and functional impacts.
The aging surgical population increasingly includes individuals with dementia.

Conclusions:

POCD needs to be understood in the context of other neurocognitive disorders.
A standardized approach to POCD, aligned with geriatric medicine, is crucial.
Anesthesiologists require enhanced knowledge to manage perioperative cognitive changes in aging patients.