Related Experiment Video

Updated: Feb 9, 2026

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction
10:35

Novel Diagnostics in Revision Arthroplasty: Implant Sonication and Multiplex Polymerase Chain Reaction

Published on: December 3, 2017

11.6K

Prognostic Factors of Pediatric Revision Ossicular Chain Reconstruction

Thomas M Kaffenberger1, Nandini Govil1, Amber D Shaffer2

  • 1Department of Otolaryngology, University of Pittsburgh School of Medicine.

Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [And] European Academy of Otology and Neurotology
|June 12, 2018
PubMed

Insights

Revision ossicular chain reconstruction (OCR) in children significantly improves hearing outcomes for conductive hearing loss. Factors like cholesteatoma and surgical approach influence the need for further revisions.

Area of Science:

  • Otolaryngology
  • Pediatric Surgery
  • Audiology

Background:

  • Conductive hearing loss can significantly impact a child's development and quality of life.
  • Ossicular chain reconstruction (OCR) is a surgical intervention to restore hearing, but revisions are sometimes necessary.
  • Up to 40% of pediatric OCRs may require revision surgery.

Purpose of the Study:

  • To evaluate the effectiveness of revision ossicular chain reconstruction (OCR) in improving hearing outcomes in pediatric patients.
  • To identify prognostic factors associated with successful revision OCR procedures.

Main Methods:

  • A retrospective review was conducted at a tertiary referral center, analyzing data from 2003 to 2014.
  • Included were pediatric patients who underwent at least two OCR procedures on the same ear.
  • Pre- and postoperative audiograms were used to assess changes in pure-tone averages (PTA), speech recognition thresholds, and air-bone gaps.

Main Results:

  • Revision OCRs led to significant improvements in PTA, speech recognition thresholds, and air-bone gaps (p<0.05).
  • Normal hearing (PTA < 25 dB) returned in 14% of patients post-revision.
  • Cholesteatoma at the time of first revision increased the likelihood of further revisions (HR: 10.3, p=0.013).

Conclusions:

  • Revision OCR is an effective method for addressing residual conductive hearing loss after initial OCR in children.
  • Surgical factors such as the presence of cholesteatoma and the technique used (canal wall up mastoidectomy) can predict the need for additional revisions.
Abstract

More Related Videos

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure05:16

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure

Published on: June 10, 2025

655
The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report07:45

The Use of Mixed Reality in Custom-Made Revision Hip Arthroplasty: A First Case Report

Published on: August 4, 2022

3.9K

Related Concept Videos

Electron Transport Chains01:28

Electron Transport Chains

The final stage of cellular respiration is oxidative phosphorylation that consists of two steps: the electron transport chain and chemiosmosis. The electron transport chain is a set of proteins found in the inner mitochondrial membrane in eukaryotic cells. Its primary function is to establish a proton gradient that can be used during chemiosmosis to produce ATP and generate electron carriers, such as NAD+ and FAD, that are used in glycolysis and the citric acid cycle.
The ETC is comprised of...
112.6K
Radical Chain-Growth Polymerization: Chain Branching01:17

Radical Chain-Growth Polymerization: Chain Branching

The skeletal structure of polymers synthesized via radical polymerization is always branched. For example, the polymerization of ethylene by radical polymerization results in a low-density grade of polyethylene with a heavily branched skeletal structure. Here, the radical site abstracts hydrogen from the growing chain, and the radical site shifts from the end (a primary carbon center) to anywhere within the growing chain (a secondary carbon center). Consequently, the part of the chain from the...
2.5K
Transcription Factors02:16

Transcription Factors

Tissue-specific transcription factors contribute to diverse cellular functions in mammals. For example, the gene for beta globin, a major component of hemoglobin, is present in all cells of the body. However, it is only expressed in red blood cells because the transcription factors that can bind to the promoter sequences of the beta globin gene are only expressed in these cells. Tissue-specific transcription factors also ensure that mutations in these factors may impair only the function of...
82.8K
Pharmacokinetics in Pediatric Patients: Drug Excretion01:26

Pharmacokinetics in Pediatric Patients: Drug Excretion

In pediatric medicine, understanding the renal function and drug elimination nuances is crucial for administering safe and effective treatments. Newborns, in particular, display markedly slower renal functions than adults, profoundly affecting how drugs are cleared from their bodies. This slower drug clearance requires clinicians to extend the dosing intervals for many medications to prevent drug accumulation and toxicity while ensuring therapeutic efficacy.One key area where these adjustments...
266
Reconstruction of Signal using Interpolation01:10

Reconstruction of Signal using Interpolation

Signal processing techniques are essential for accurately converting continuous signals to digital formats and vice versa. When a continuous signal is sampled with a period T, the resulting sampled signal exhibits replicas of the original spectrum in the frequency domain, spaced at intervals equal to the sampling frequency. To handle this sampled signal, a zero-order hold method can be applied, which creates a piecewise constant signal by retaining each sample's value until the next...
735
Factors Affecting Solubility04:01

Factors Affecting Solubility

Compared with pure water, the solubility of an ionic compound is less in aqueous solutions containing a common ion (one also produced by dissolution of the ionic compound). This is an example of a phenomenon known as the common ion effect, which is a consequence of the law of mass action that may be explained using Le Chȃtelier’s principle. Consider the dissolution of silver iodide:
37.2K