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Overcoming endocrine resistance in metastatic hormone receptor-positive breast cancer

Anishka D'Souza1, Darcy Spicer1, Janice Lu2

  • 1USC Norris Comprehensive Cancer Center, 1441 Eastlake Avenue, Los Angeles, CA, 90033, USA.

Journal of Hematology & Oncology
|June 13, 2018
PubMed

Insights

Treatment for metastatic hormone receptor-positive breast cancer now includes CDK4/6 inhibitors, improving progression-free survival. Further research explores PI3K and mTOR inhibitors for endocrine resistance, guiding optimal therapy sequencing.

Area of Science:

  • Oncology
  • Endocrinology
  • Pharmacology

Background:

  • Hormone receptor-positive breast cancer (HR+ BC) is often treated with endocrine therapy.
  • Endocrine resistance is a significant challenge in managing metastatic HR+ BC.
  • Novel therapeutic strategies are needed to overcome endocrine resistance.

Purpose of the Study:

  • To review current treatment strategies for metastatic HR+ BC.
  • To discuss the role of newer agents like CDK4/6 inhibitors.
  • To explore the potential of PI3K and mTOR inhibitors in endocrine-resistant settings.

Main Methods:

  • Literature review of clinical trials and studies.
  • Analysis of treatment outcomes for various drug combinations.
  • Evaluation of factors influencing therapeutic sequencing.

Main Results:

  • CDK4/6 inhibitors have demonstrated significant improvements in progression-free survival.
  • PI3K and mTOR inhibitors are being investigated as subsequent lines of therapy.
  • Optimal sequencing depends on patient-specific factors.

Conclusions:

  • CDK4/6 inhibitors represent a major advancement in metastatic HR+ BC treatment.
  • Targeted therapies like PI3K and mTOR inhibitors offer promise for endocrine resistance.
  • Personalized treatment sequencing is crucial for maximizing patient benefit.

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