Related Experiment Video
Updated: Feb 9, 2026
13:04
Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
Published on: March 1, 2019
9.3K
Hypoxia and Noncoding RNAs in Taxane Resistance.
Perla Pucci1, Pasquale Rescigno2, Semini Sumanasuriya3
1School of Life Health and Chemical Sciences, The Open University, Milton Keynes, UK.
Trends in Pharmacological Sciences
|June 13, 2018
Summary
Taxanes are vital chemotherapy drugs, but cancer cells can become resistant. Understanding the complex mechanisms of taxane resistance is key to developing new treatments for resistant cancers.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Taxanes are widely used chemotherapeutics for various cancers.
- Cancer cells frequently develop resistance to taxanes, limiting treatment efficacy.
- New strategies are needed to overcome taxane resistance and improve patient outcomes.
Purpose of the Study:
- To review and consolidate the known causes of taxane resistance.
- To propose an integrated model of the 'taxane resistance phenome'.
- To guide the development of novel therapeutic strategies for taxane-resistant neoplasms.
Main Methods:
- Literature review focusing on molecular mechanisms of taxane resistance.
- Analysis of various cellular pathways and effectors implicated in resistance.
- Conceptualization of an integrated model for taxane resistance.
Main Results:
- Taxane resistance is multifactorial, involving efflux pumps, DNA repair, and hypoxia.
- Non-coding RNAs and epigenetic factors are emerging as significant contributors to resistance.
- An integrated understanding of these diverse mechanisms is lacking.
Conclusions:
- An integrated model of the 'taxane resistance phenome' is proposed.
- This model can facilitate the development of more effective therapies for resistant cancers.
- Further research into the interplay of resistance mechanisms is warranted.
Related Concept Videos
02:30siRNA - Small Interfering RNAs
18.7K
Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
In the cytoplasm, siRNA is processed from a double-stranded RNA, which comes from either endogenous DNA transcription or exogenous sources like a virus. This double-stranded RNA is then cleaved by the...
18.7K
02:39lncRNA - Long Non-coding RNAs
10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
02:39lncRNA - Long Non-coding RNAs
3.7K
3.7K
02:57piRNA - Piwi-interacting RNAs
7.7K
PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
7.7K
01:23Hypoxia
2.2K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.2K
02:30Small interfering RNAs (siRNA)
4.6K
4.6K