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Hypoxia and Noncoding RNAs in Taxane Resistance

Perla Pucci1, Pasquale Rescigno2, Semini Sumanasuriya3

  • 1School of Life Health and Chemical Sciences, The Open University, Milton Keynes, UK.

Trends in Pharmacological Sciences
|June 13, 2018
PubMed

Insights

Taxanes are vital chemotherapy drugs, but cancer cells can become resistant. Understanding the complex mechanisms of taxane resistance is key to developing new treatments for resistant cancers.

Area of Science:

  • Oncology
  • Pharmacology
  • Molecular Biology

Background:

  • Taxanes are widely used chemotherapeutics for various cancers.
  • Cancer cells frequently develop resistance to taxanes, limiting treatment efficacy.
  • New strategies are needed to overcome taxane resistance and improve patient outcomes.

Purpose of the Study:

  • To review and consolidate the known causes of taxane resistance.
  • To propose an integrated model of the 'taxane resistance phenome'.
  • To guide the development of novel therapeutic strategies for taxane-resistant neoplasms.

Main Methods:

  • Literature review focusing on molecular mechanisms of taxane resistance.
  • Analysis of various cellular pathways and effectors implicated in resistance.
  • Conceptualization of an integrated model for taxane resistance.

Main Results:

  • Taxane resistance is multifactorial, involving efflux pumps, DNA repair, and hypoxia.
  • Non-coding RNAs and epigenetic factors are emerging as significant contributors to resistance.
  • An integrated understanding of these diverse mechanisms is lacking.

Conclusions:

  • An integrated model of the 'taxane resistance phenome' is proposed.
  • This model can facilitate the development of more effective therapies for resistant cancers.
  • Further research into the interplay of resistance mechanisms is warranted.
Keywords:
Taxanesdrug resistanceexperimental therapieshypoxianon-coding RNAs

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