Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Elastosis in benign and malignant breast disease.

N A Parfrey, C T Doyle

    Human Pathology
    |July 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Elastosis, or increased elastic fibers, progresses with breast disease severity. This finding was observed in fibrocystic disease and breast cancers, indicating a link between elastosis and epithelial hyperplasia.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    The role of alcohol in deaths presenting to the coroner's service in Cork City and County.

    Irish medical journal·2009
    Same author

    SPG15, a new locus for autosomal recessive complicated HSP on chromosome 14q.

    Neurology·2001
    Same author

    Phenotype of AD-HSP due to mutations in the SPAST gene: comparison with AD-HSP without mutations.

    Neurology·2001
    Same author

    Age-related cognitive decline in hereditary spastic paraparesis linked to chromosome 2p.

    Neurology·2000
    Same author

    Expansion of peripheral blood CD5+ B cells is associated with mild disease in chronic hepatitis C virus infection.

    Journal of hepatology·2000
    Same author

    bcl-2 protein expression is associated with better prognosis in colorectal cancer.

    Histopathology·1999

    Area of Science:

    • Pathology
    • Oncology
    • Breast Disease Research

    Background:

    • Elastosis, characterized by elastic fiber accumulation, is frequently observed alongside breast carcinoma.
    • Epitheliosis (epithelial hyperplasia) within fibrocystic disease is considered a premalignant component.
    • The relationship between elastosis progression and the severity of breast disease warrants further investigation.

    Purpose of the Study:

    • To investigate the hypothesis that elastosis increases with the severity of epitheliosis in fibrocystic breast disease.
    • To determine if elastosis further increases with the progression to intraductal and infiltrating ductal carcinoma.
    • To quantitatively assess the correlation between elastosis and the stages of breast disease.

    Main Methods:

    • Analysis of breast tissue samples from 84 women in their fifth decade.

    Related Experiment Videos

  • Categorization of samples into six groups: fibrocystic disease without epitheliosis, with mild, moderate, or severe epitheliosis, intraductal carcinoma, and infiltrating duct carcinoma.
  • Grading of periductal and stromal elastosis on a scale of 0 to 4 (absent to massive).

    • Main Results:

    • A significant progressive increase in both periductal elastosis (R = 0.54; P < 0.001) and stromal elastosis (R = 0.75; P < 0.001) was observed.
    • Elastosis grades correlated positively with the severity of epitheliosis in fibrocystic disease.
    • Elastosis levels were higher in cases of intraductal and infiltrating ductal carcinoma compared to fibrocystic disease.

    Conclusions:

    • The degree of elastosis significantly increases with the progression of breast disease, from fibrocystic changes to invasive carcinoma.
    • Elastosis serves as a potential biomarker for the severity and advancement of breast pathologies.
    • Further research into the role of elastosis in breast cancer development and progression is recommended.