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Modeling Hepatitis B Virus Infection in Non-Hepatic 293T-NE-3NRs Cells
Published on: June 5, 2020
Ideal Cure for Hepatitis B Infection: The Target is in Sight
Shrihari A Anikhindi1,2, Ashish Kumar1,2, Praveen Sharma1,2
1Department of Gastroenterology, Sir Ganga Ram Hospital, New Delhi, India.
Abstract:
Hepatitis B virus (HBV) is one of the most common causes of liver cirrhosis and hepatocellular carcinoma. Despite recent strides in pharmacotherapy, complete cure of HBV infection still remains an enigma. The biggest obstacle in HBV therapy is clearance of covalently closed circular deoxyribonucleic acid (cccDNA). We discuss about the role of cccDNA in HBV life cycle, efficacy and shortcomings of currently available antivirals as well as promising novel targets to achieve ideal HBV cure.
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