Potential antibacterial mechanism of silver nanoparticles and the optimization of orthopedic implants by advanced
Yun'an Qing1, Lin Cheng2, Ruiyan Li1
1Orthopaedic Medical Center, The Second Hospital of Jilin University, Changchun 130041, People's Republic of China.
Abstract:
Infection, as a common postoperative complication of orthopedic surgery, is the main reason leading to implant failure. Silver nanoparticles (AgNPs) are considered as a promising antibacterial agent and always used to modify orthopedic implants to prevent infection. To optimize the implants in a reasonable manner, it is critical for us to know the specific antibacterial mechanism, which is still unclear. In this review, we analyzed the potential antibacterial mechanisms of AgNPs, and the influences of AgNPs on osteogenic-related cells, including cellular adhesion, proliferation, and differentiation, were also discussed. In addition, methods to enhance biocompatibility of AgNPs as well as advanced implants modifications technologies were also summarized.
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