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TNF Receptor 2 Makes Tumor Necrosis Factor a Friend of Tumors

Yuqiao Sheng1, Feng Li2, Zhihai Qin1

  • 1Medical Research Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.

Frontiers in Immunology
|June 13, 2018
PubMed

Insights

Tumor necrosis factor receptor 2 (TNFR2) promotes tumor growth by supporting cancer cell proliferation and immune suppression. Targeting TNFR2 may offer a novel cancer therapy strategy.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Tumor necrosis factor (TNF) typically suppresses tumors via TNF receptor 1 (TNFR1).
  • TNF receptor 2 (TNFR2) is expressed on tumor cells and immune cells, altering TNF's role.
  • TNFR2 promotes tumor progression and immune evasion, contrasting with TNFR1's function.

Purpose of the Study:

  • To investigate the expression and function of TNFR2 within the tumor microenvironment.
  • To summarize recent advancements in understanding TNFR2-mediated mechanisms in cancer.
  • To evaluate the therapeutic potential of targeting TNFR2 in cancer treatment.

Main Methods:

  • Review of existing literature on TNFR2 expression and function in various cancers.
  • Analysis of studies detailing TNFR2's role in tumor cell proliferation and immune cell modulation.
  • Synthesis of data on TNFR2-dependent signaling pathways in carcinogenesis.

Main Results:

  • TNFR2 expression is found on both tumor cells and immunosuppressive immune cells.
  • TNFR2 activation by TNF shifts its function from tumor-suppressive to tumor-promoting.
  • TNFR2 promotes tumor cell proliferation and activates immunosuppressive cells, facilitating immune escape.

Conclusions:

  • TNFR2 plays a critical role in promoting tumor growth and immune evasion.
  • Targeting TNFR2 presents a promising therapeutic avenue for cancer treatment.
  • Further research into TNFR2-targeted therapies is warranted.
Keywords:
TNF receptor 2macrophagesmyeloid-derived suppressor cellsregulatory T cellstumortumor necrosis factor

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