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Ultrasound-based Pulse Wave Velocity Evaluation in Mice
Published on: February 14, 2017
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Collective cell migration without proliferation: density determines cell velocity and wave velocity.
Sham Tlili1,2, Estelle Gauquelin3, Brigitte Li1
1Laboratoire Matière et Systèmes Complexes, Université Denis Diderot - Paris 7, CNRS UMR 7057, Condorcet building, 10 rue Alice Domon et Léonie Duquet, 75205 Paris Cedex 13, France.
Royal Society Open Science
|June 13, 2018
Summary
Collective cell migration, crucial for development and disease, was studied by inhibiting cell proliferation. Velocity waves propagate backward, influenced by cell density and effective radius, revealing mechanisms of long-range information transfer.
Area of Science:
- Cell Biology
- Biophysics
- Developmental Biology
Background:
- Collective cell migration is fundamental to embryogenesis, wound healing, and tumor metastasis.
- Understanding cell movement dynamics away from the leading edge is critical for these processes.
Purpose of the Study:
- To investigate the space-time characteristics of cell monolayer migration.
- To determine factors influencing cell movement far from the leading edge.
- To model the interplay between cell density, velocity, and polarity.
Main Methods:
- Cell monolayer migration experiments with inhibited cell proliferation.
- Quantification of velocity profiles over large length and time scales.
- Development of a model combining conservation laws, mechanical properties, and strain-polarity coupling.
Main Results:
- Inhibiting proliferation allowed for long-duration migration and revealed backward-propagating velocity waves.
- Wave frequency depends solely on leading-edge cell density; velocities correlate with cell effective radius.
- Inhibiting lamellipodia reduced cell velocity and wave frequency.
Conclusions:
- The study disentangles the roles of active velocity and proliferation in monolayer migration.
- A model highlights strain-polarity coupling and density as key for long-range information propagation.
- Cell polarity is maintained far from the leading edge through a strain-polarity feedback mechanism.
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