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Evaluating the Hypothalamic-Pituitary-Thyroid (HPT) Axis in Mice
1Department of Medicine, Rutgers-Robert Wood Johnson Medical School, Henry Rutgers Term Chair and Chancellor Scholar Rutgers, The State University of New Jersey, New Brunswick, NJ, 08901, USA. few11@rwjms.rutgers.edu.
Abstract:
As the genome of experimental animals has become easier to manipulate, a number of mouse models have been developed to understand in vivo thyroid hormone action. A major site of thyroid hormone action is the HPT axis. While several methods are available that provide a detailed understanding of the HPT axis in mice, many authors choose to include only cursory data about this axis, which can lead to erroneous conclusions about in vivo thyroid hormone action. A standard protocol is proposed to evaluate the HPT axis in mice.
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