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Updated: Feb 9, 2026

Injectable Supramolecular Polymer-Nanoparticle Hydrogels for Cell and Drug Delivery Applications
Published on: February 7, 2021
Application of bi-nanoparticle on dose enhancement effect in two different polymer gel dosimeter using
P Sathiyaraj1, E James Jebaseelan Samuel2
1Department of Physics, Medical Dosimetry Laboratory, School of Advanced Sciences, VIT-University, Vellore, Tamil Nadu, India.
Purpose:
This study aimed at proving the ability of bismuth-nanoparticle (Bi-np) in dose enhancement effect (DEE) using the polymer gel dosimeter. Two different polymer gels, namely poly acrylamide gelatin tetrakis hydroxymethyl phosphonium chloride (PAGAT) and N-isopropylacrylamide (NIPAM) gels were chosen for this study.
Materials And Methods:
The gels were doped with Bi-np particle with various concentrations of 0.5 mM, 1 mM, and 2.5 mM and were then irradiated with a CO-60 gamma radiation source of energy 1.25 MeV. Gel samples were analyzed by spectrophotometer. The dose enhancement factor (DEF) was calculated for both gels for all concentrations of Bi-np particle.
Results:
The higher DEF for PAGAT and NIPAM was calculated as 1.3415 and 1.1823, respectively, for 0.5 mM concentration of Bi-np.
Conclusion:
From our results, we infer that 0.5 mM is the optimal concentration in polymer gel to obtain good DEEs in the energy range of 1.25 MeV.
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