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Biocomputing for Portable, Resettable, and Quantitative Point-of-Care Diagnostics: Making the Glucose Meter a

Jingjing Zhang1, Yi Lu1

  • 1Department of Chemistry, Beckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, IL, 61801, USA.

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This study introduces biocomputing on personal glucose meters for portable diagnostics. It enables versatile biomolecular logic gates for point-of-care detection of various analytes and diseases.

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Area of Science:

  • Biocomputing
  • Molecular Diagnostics
  • Point-of-Care Technology

Background:

  • Biomolecular logic gates are challenging to implement in portable, resettable, and quantitative sensing systems for low-resource point-of-care diagnostics.
  • Existing systems lack the modularity and convenience for widespread clinical application.

Purpose of the Study:

  • To develop the first biocomputing platform integrated with personal glucose meters (PGMs) for advanced biosensing.
  • To create a generalizable system for implementing diverse biomolecular logic gate responses for various biological species.
  • To establish a resettable concatenated logical gate platform for enhanced diagnostic capabilities.

Main Methods:

  • Utilized glucose and reduced nicotinamide adenine dinucleotide as signal outputs.
  • Employed DNAzymes and protein enzymes as core building blocks for logic gate construction.
  • Demonstrated a platform capable of YES, NOT, INHIBIT, NOR, NAND, and OR logic gate operations.

Main Results:

  • Successfully installed multiple logic gate responses for detecting cations, anions, organic metabolites, and enzymes.
  • Developed a resettable concatenated logical gate platform.
  • Showcased the system's high modularity and broad applicability to various diseases.

Conclusions:

  • Biocomputing on PGMs offers a novel, convenient, and portable solution for point-of-care diagnostics in resource-limited settings.
  • This approach expands the clinical utility of PGMs and opens new avenues for intelligent, on-site biomolecular diagnostic devices.