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Published on: May 31, 2016
Hippocampal Calcifications: Risk Factors and Association with Cognitive Function.
Esther J M de Brouwer1, Remko Kockelkoren1, Jules J Claus1
1From the Department of Geriatrics (E.J.M.d.B., H.L.K.), Department of Radiology (R.K., W.P.T.M.M., J.H., P.A.d.J.), and Julius Center for Health Sciences and Primary Care, Department of Epidemiology (M.I.G.), University Medical Center Utrecht, Room B05.2.25, PO Box 85500, 3508 GA Utrecht, the Netherlands; and Departments of Neurology (J.J.C.), Geriatrics (A.d.J.), and Radiology (T.E.F.J.), Tergooi Hospital, Hilversum, the Netherlands.
Older age, diabetes mellitus, and smoking increase the risk of hippocampal calcifications. However, these calcifications did not correlate with cognitive function in patients with memory issues.
Area of Science:
- Neurology
- Radiology
- Geriatrics
Background:
- Hippocampal calcifications are observed in patients with memory complaints.
- Understanding their risk factors and association with cognitive decline is crucial for diagnosis and management.
Purpose of the Study:
- To identify risk factors associated with hippocampal calcifications.
- To investigate the relationship between hippocampal calcifications and cognitive function in patients presenting with memory complaints.
Main Methods:
- Retrospective study of 1991 patients from a memory clinic.
- Assessment of vascular risk factors: hypertension, diabetes mellitus, hyperlipidemia, and smoking.
- Cognitive screening using the Cambridge Cognitive Examination and CT scan analysis for hippocampal calcifications.
Main Results:
- 19.1% of patients had hippocampal calcifications.
- Older age, diabetes mellitus, and smoking were significantly associated with the presence of hippocampal calcifications.
- No association was found between the presence or severity of hippocampal calcifications and cognitive function.
Conclusions:
- Older age, diabetes mellitus, and smoking are identified as risk factors for hippocampal calcifications.
- Hippocampal calcifications were not found to be associated with impaired cognitive function in this patient cohort.
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