Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Response Surface Methodology01:16

Response Surface Methodology

673
Response Surface Methodology (RSM) is a collection of statistical and mathematical techniques used to develop, improve, and optimize processes. It is particularly valuable when many input variables or factors potentially influence a response variable.
The process of RSM involves several key steps:
673
Contaminants and Errors01:16

Contaminants and Errors

382
Effective sample preparation is crucial for accurate and reliable laboratory analysis. During this process, two significant sources of error can arise: concentration bias from improper sample splitting and contamination caused by methods used to reduce particle size, such as grinding or homogenization. Identifying and minimizing these potential errors is crucial to ensuring the validity of the analysis.
Another key consideration is determining the appropriate number of samples required to...
382
Radiological Investigation I: X-ray and CT01:30

Radiological Investigation I: X-ray and CT

1.2K
Radiological investigations, including X-rays and computed tomography (CT) scans, are critical for diagnosing and evaluating various medical conditions. These imaging techniques provide valuable insights into the body's internal structures, aiding in the detection of abnormalities, assessment of disease progression, and development of treatment strategies. This article delves into two primary radiological investigations, chest X-rays and CT scans, outlining their purpose, procedures, and...
1.2K
Dose Size and Dosing Frequency: Determination Methods01:21

Dose Size and Dosing Frequency: Determination Methods

315
Determining the optimal dose size and dosing frequency in pharmacotherapy is crucial for achieving therapeutic effectiveness while minimizing adverse effects. This article explores the methodologies employed in determining these parameters, focusing on their significance and interplay to tailor dosing regimens.Dose Size: Dose size refers to the amount of a drug administered in a single dose. It is determined based on the drug's pharmacodynamics and pharmacokinetics properties and...
315
Determination of Multiple Dosing Parameters: Loading and Maintenance Doses01:25

Determination of Multiple Dosing Parameters: Loading and Maintenance Doses

246
A loading dose is an essential pharmacological strategy to rapidly achieve the target plasma drug concentration necessary for an immediate therapeutic effect. This approach is especially critical for drugs characterized by slow absorption or extended half-lives, where delaying therapeutic plasma levels could compromise treatment outcomes. By administering a loading dose, clinicians ensure a prompt onset of drug action, even for agents with complex pharmacokinetic profiles.Achieving steady-state...
246
Rational Dosage Regimen: Maintenance Dose and Loading Dose01:24

Rational Dosage Regimen: Maintenance Dose and Loading Dose

5.5K
A rational dosage regimen considers a drug's pharmacokinetics, including its absorption, distribution, metabolism, and elimination from the body. By understanding these factors, the appropriate dosage can be determined, and the dosing schedule can be designed to achieve and maintain the desired therapeutic effect while minimizing adverse effects.
In most cases, drugs are administered repetitively or infused continuously to maintain a steady-state concentration in the body. At a steady...
5.5K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Effect of Repeated Low-Dose UVR Exposure on Skin Inflammation Threshold, Skin Biomarkers, and Vitamin D in Healthy Adults.

The Journal of investigative dermatology·2025
Same author

Modeling Fallout from Nuclear Weapon Detonations: Efficient Activity and Dose Calculation of Radionuclides and Their Progeny.

Health physics·2024
Same author

Surface-clearance levels for the normal reuse of objects for 413 radionuclides.

Journal of radiological protection : official journal of the Society for Radiological Protection·2022
Same author

Stratum corneum biomarkers after in vivo repeated exposure to sub-erythemal dosages of ultraviolet radiation in unprotected and sunscreen (SPF 50+) protected skin.

Photodermatology, photoimmunology & photomedicine·2021
Same author

Detection of radioactivity of unknown origin: Protective actions based on inverse modelling.

Journal of environmental radioactivity·2021
Same author

Dark cyclobutane pyrimidine dimers are formed in the epidermis of Fitzpatrick skin types I/II and VI in vivo after exposure to solar-simulated radiation.

Pigment cell & melanoma research·2020

Related Experiment Video

Updated: Feb 9, 2026

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
11:45

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

12.6K

SUDOQU, a new dose-assessment methodology for radiological surface contamination.

Teun van Dillen1, Arjan van Dijk

  • 1Centre for Environmental Safety and Security, National Institute for Public Health and the Environment (RIVM), PO Box 1, NL-3720 BA, Bilthoven, The Netherlands.

Journal of Radiological Protection : Official Journal of the Society for Radiological Protection
|June 13, 2018
PubMed
Summary

A new Surface Dose Quantification (SUDOQU) methodology assesses annual effective dose from surface contamination. It models time-dependent contamination levels for consumer and worker scenarios, aiding in setting safety criteria for goods and environments.

More Related Videos

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.8K
Practical Methodology of Cognitive Tasks Within a Navigational Assessment
05:19

Practical Methodology of Cognitive Tasks Within a Navigational Assessment

Published on: June 1, 2015

14.0K

Related Experiment Videos

Last Updated: Feb 9, 2026

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition
11:45

Functional Interrogation of Adult Hypothalamic Neurogenesis with Focal Radiological Inhibition

Published on: November 14, 2013

12.6K
Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition
06:20

Irradiator Commissioning and Dosimetry for Assessment of LQ α and β Parameters, Radiation Dosing Schema, and in vivo Dose Deposition

Published on: March 11, 2021

7.8K
Practical Methodology of Cognitive Tasks Within a Navigational Assessment
05:19

Practical Methodology of Cognitive Tasks Within a Navigational Assessment

Published on: June 1, 2015

14.0K

Area of Science:

  • Radiological Protection
  • Environmental Science
  • Radiation Dosimetry

Background:

  • Assessing radiological surface contamination is crucial for public and occupational safety.
  • Existing methods may not adequately address time-dependent contamination scenarios.
  • Deriving effective dose from surface contamination requires comprehensive modeling.

Purpose of the Study:

  • Introduce and describe the SUDOQU methodology for quantifying surface contamination dose.
  • Provide a tool for deriving criteria for surface contamination, including limiting values and screening levels.
  • Address both consumer and worker exposure scenarios related to contaminated goods and environments.

Main Methods:

  • Developed a mass (activity)-balance model incorporating radioactive decay, removal, and deposition.
  • Derived time-dependent equations for surface, air, and skin contamination levels.
  • Integrated these levels into annual effective dose calculations, considering multiple exposure pathways.

Main Results:

  • SUDOQU provides time-dependent surface contamination assessments for various environments.
  • The methodology accommodates both limited-item (consumer) and continuous-flow (worker) exposure scenarios.
  • Introduced the concept of limiting effective surface dose for conservative dose assessments.

Conclusions:

  • SUDOQU offers a robust framework for assessing annual effective dose from radiological surface contamination.
  • The methodology is applicable to diverse fields including trade, waste management, and emergency preparedness.
  • SUDOQU supports radiation protection experts and policymakers in establishing safety standards.