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Peptide hormones shared by the neuroendocrine and immunologic systems
Journal of Immunology (Baltimore, Md. : 1950)
|August 1, 1985
Summary
The immune system communicates with the neuroendocrine system, challenging previous assumptions. Recent research reveals shared hormones and receptors, indicating a bidirectional control circuit between these systems.
Area of Science:
- Neuroendocrinology
- Immunology
- Psychoneuroimmunology
Background:
- Traditionally, the neuroendocrine system's control over immune functions is well-established.
- Emerging evidence highlights a reciprocal relationship, where the immune system influences neuroendocrine functions.
Purpose of the Study:
- To review recent studies providing a molecular basis for bidirectional communication between the immune and neuroendocrine systems.
- To discuss the integrated nature of these systems and their regulatory mechanisms.
Main Methods:
- Review of recent scientific literature on neuroendocrine-immune interactions.
- Analysis of studies identifying shared hormones and receptors.
- Discussion of potential hypothalamic and immunologic regulatory pathways.
Main Results:
- The immune and neuroendocrine systems share common hormones (e.g., corticotropin, thyrotropin, endorphins) and their receptors.
- This shared molecular machinery forms the basis for bidirectional communication.
- Evidence suggests a highly integrated circuit rather than a one-way control.
Conclusions:
- The neuroendocrine and immune systems are not separate but form an integrated circuit.
- Bidirectional communication is mediated by shared hormonal and receptor systems.
- Further research into hypothalamic and immunologic controls of this circuit is warranted.