Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Ulcerative Colitis in IBD01:29

Drugs for Treatment of Ulcerative Colitis in IBD

527
Ulcerative colitis is a chronic inflammatory condition primarily affecting the colon and rectum. The primary drugs used in the treatment of ulcerative colitis are aminosalicylates. They exhibit anti-inflammatory and immunosuppressive properties. They modulate inflammatory mediators and inhibit the activity of nuclear factor κB (NF-κB). Aminosalicylates also reduce inflammation by inhibiting prostaglandin and leukotriene production and decreasing neutrophil chemotaxis and superoxide...
527
Inflammatory Bowel Disease I: Ulcerative Colitis01:27

Inflammatory Bowel Disease I: Ulcerative Colitis

1.1K
Introduction
Inflammatory bowel disease, or IBD, encompasses a group of disorders characterized by chronic inflammation or ulceration of the gastrointestinal tract.
Risk Factors
The exact cause of IBD remains unclear, although it is believed to be due to a mix of genetic, environmental, microbial, and immune factors. Genetic factors are significant in determining susceptibility to IBD, with family history being a critical risk factor. Individuals with a first-degree relative who has IBD are at...
1.1K
Indicators02:39

Indicators

61.1K
Certain organic substances change color in dilute solution when the hydronium ion concentration reaches a particular value. For example, phenolphthalein is a colorless substance in any aqueous solution with a hydronium ion concentration greater than 5.0 × 10−9 M (pH < 8.3). In more basic solutions where the hydronium ion concentration is less than 5.0 × 10−9 M (pH > 8.3), it is red or pink. Substances such as phenolphthalein, which can be used to determine the pH of a solution, are...
61.1K
Correlations02:20

Correlations

36.4K
Correlation means that there is a relationship between two or more variables (such as ice cream consumption and crime), but this relationship does not necessarily imply cause and effect. When two variables are correlated, it simply means that as one variable changes, so does the other. We can measure correlation by calculating a statistic known as a correlation coefficient. A correlation coefficient is a number from -1 to +1 that indicates the strength and direction of the relationship between...
36.4K
Correlation and Causation01:27

Correlation and Causation

42.9K
Statistical tests can calculate whether there is a relationship, or correlation, between independent and dependent variables. An indirect relationship of the variables signifies a correlation, while a direct relationship shows causation. If it is determined that no connection exists between the variables, then the correlation is a coincidence.
Correlation versus Causation
If the dependent variable increases or decreases when the independent variable increases, there is a positive or negative...
42.9K
Reliability and Validity01:29

Reliability and Validity

14.1K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
14.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: The STARD-AI reporting guideline for diagnostic accuracy studies using artificial intelligence.

Nature medicine·2026
Same author

What influences whether researchers adhere to healthcare reporting guidelines successfully? A thematic synthesis.

Research integrity and peer review·2026
Same author

A scoping review of guidance on sharing trial results with patients and the public finds inconsistent recommendations and limited methodological development.

Journal of clinical epidemiology·2026
Same author

Stakeholder perspectives on potential open-label bias in patient-reported outcome results from cancer clinical trials: evidence from the IMPROvE project.

Value in health : the journal of the International Society for Pharmacoeconomics and Outcomes Research·2026
Same author

SPIRIT 2025 statement: updated guideline for protocols of randomised trials.

Lancet (London, England)·2026
Same author

Recommendations for studying the safety, efficacy and durability of intracranial aneurysm devices.

European stroke journal·2026

Related Experiment Video

Updated: Feb 9, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.7K

Correlation Between Endoscopic and Histological Activity in Ulcerative Colitis Using Validated Indices.

Nazneen R Irani1, Lai Mun Wang2, Gary S Collins3

  • 1Translational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.

Journal of Crohn'S & Colitis
|June 13, 2018
PubMed
Summary

The Ulcerative Colitis Endoscopic Index of Severity (UCEIS) strongly correlates with histological indices (NI and RHI) in ulcerative colitis patients. A UCEIS score of 0 indicates complete mucosal healing and absence of microscopic disease activity.

More Related Videos

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.6K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.6K

Related Experiment Videos

Last Updated: Feb 9, 2026

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System
15:49

Flexible Colonoscopy in Mice to Evaluate the Severity of Colitis and Colorectal Tumors Using a Validated Endoscopic Scoring System

Published on: October 16, 2013

32.7K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

1.6K
Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model
09:11

Systematic Scoring Analysis for Intestinal Inflammation in a Murine Dextran Sodium Sulfate-Induced Colitis Model

Published on: February 14, 2021

10.6K

Area of Science:

  • Gastroenterology
  • Inflammatory Bowel Disease Research
  • Clinical Endoscopy

Background:

  • Endoscopic and histological assessments are crucial for monitoring ulcerative colitis (UC) disease activity.
  • Existing validated endoscopic and histological indices for UC lack direct correlation studies.
  • Accurate assessment of UC disease activity is vital for effective treatment strategies.

Purpose of the Study:

  • To correlate the Ulcerative Colitis Endoscopic Index of Severity (UCEIS) with two novel histological indices: Nancy Index (NI) and Robarts' Histological Index (RHI).
  • To evaluate the relationship between endoscopic findings and microscopic disease activity in patients with established UC.
  • To determine the optimal endoscopic score indicative of complete mucosal healing.

Main Methods:

  • A single-center cohort study included 125 patients with established UC.
  • Endoscopic procedures were performed by a single endoscopist, with UCEIS scored in the distal colon.
  • Biopsies from the worst affected area were assessed by a pathologist for NI and RHI, blinded to endoscopic findings.

Main Results:

  • The UCEIS demonstrated strong positive correlations with both NI (r=0.84) and RHI (r=0.86).
  • Excellent correlation was observed between the two histological indices (NI and RHI) (r=0.92).
  • A UCEIS score of 0 was most closely associated with quiescent disease activity (absence of neutrophils on histology).

Conclusions:

  • The UCEIS is a reliable endoscopic tool that strongly correlates with histological assessments of disease activity in UC.
  • A UCEIS score of 0/8 is recommended as the definition for complete mucosal healing, signifying the absence of microscopic inflammation.
  • These findings support the use of UCEIS in conjunction with histological evaluation for comprehensive UC management.