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Validation of a whole-slide image-based teleconsultation network
Alexi Baidoshvili1, Nikolas Stathonikos2, Gerard Freling1
1Laboratory of Pathology East Netherlands, (LabPON), Hengelo, the Netherlands.
Histopathology
|June 13, 2018
Summary
A new teleconsultation network for digital pathology achieved a 97.8% concordance rate between remote digital and original diagnoses. This validates whole-slide imaging for pathology consultations, improving speed while maintaining diagnostic standards.
Area of Science:
- Digital Pathology
- Medical Informatics
- Pathology Diagnostics
Background:
- Most digital pathology validation studies are single-institute based.
- Digital pathology laboratory networks enable rapid extramural expert consultation.
- Validating inter-laboratory teleconsultation is crucial for network adoption.
Purpose of the Study:
- To validate a whole-slide image-based teleconsultation network between three independent laboratories.
- To assess the diagnostic concordance between digital and light microscopic pathology.
- To evaluate the technical performance of the digital teleconsultation system.
Main Methods:
- 90 specimens (776 slides) from three laboratories were centrally scanned at 40x magnification.
- 16 pathologists digitally assessed slides, excluding their own laboratory's cases.
- Concordance rates and technical performance (loading speed, zoom, focus) were compared.
Main Results:
- A 97.8% concordance rate was achieved between remote digital and original light microscopic diagnoses, excluding minor discrepancies.
- Two major discrepancies were identified, one due to diagnostic criteria interpretation and another due to image quality.
- Average technical performance scores indicated good loading speed, zooming latency, and focus quality.
Conclusions:
- The teleconsultation network using whole-slide images is suitable for remote digital pathology consultation.
- Digital pathology networks can enhance the speed of pathology revisions and consultations.
- Diagnostic standards can be maintained through validated teleconsultation networks.
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