Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Classification of Skeletal Muscle Fibers01:48

Classification of Skeletal Muscle Fibers

59.6K
Skeletal muscles continuously produce ATP to provide the energy that enables muscle contractions. Skeletal muscle fibers can be categorized into three types based on differences in their contraction speed and how they produce ATP, as well as physical differences related to these factors. Most human muscles contain all three muscle fiber types, albeit in varying proportions.
Slow-Twitch Muscle Fibers
Slow oxidative, muscle fibers appear red due to large numbers of capillaries and high levels of...
59.6K
Overview of Skeletal Muscle01:15

Overview of Skeletal Muscle

14.7K
Skeletal muscles are composed of a bundle of muscle fibers and are attached to bones through tendons. Each skeletal muscle fiber is a single muscle cell. The sarcolemma, the plasma membrane of a skeletal muscle cell, consists of a lipid bilayer and glycocalyx that supports muscle fibers. The sarcolemma extends into the muscle cells to form tubular structures called transverse or T-tubules. Each side of the T-tubules consists of a membrane-bound structure called the sarcoplasmic reticulum,...
14.7K
Relaxation of Skeletal Muscles01:29

Relaxation of Skeletal Muscles

5.9K
The period of muscle contraction primarily influences the duration of stimulation at the neuromuscular junction (NMJ), the presence of free calcium ions in the sarcoplasm, and the availability of energy or ATP to support contractions.
When an action potential reaches the axon terminal, it depolarizes the membrane and opens voltage-gated sodium channels. Sodium ions enter the cell, further depolarizing the presynaptic membrane. This depolarization causes voltage-gated calcium channels to open....
5.9K
lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

10.0K
In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
10.0K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

1.9K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
1.9K
Naming Skeletal Muscles01:19

Naming Skeletal Muscles

4.1K
The naming of the approximately 700 muscles in the human body is based on a set of criteria designed to provide descriptive information about each muscle, making it easier to identify and remember them.
The key factors used in naming muscles include:
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hybrid zeolitic imidazolate frameworks with catalytically active TO4 building blocks.

Angewandte Chemie (International ed. in English)Ā·2010
Same author

Whiter matter abnormalities in medication-naive subjects with a single short-duration episode of major depressive disorder.

Psychiatry researchĀ·2010
Same author

A new comorbidity index: the health-related quality of life comorbidity index.

Journal of clinical epidemiologyĀ·2010
Same author

S-adenosylmethionine inhibits the growth of cancer cells by reversing the hypomethylation status of c-myc and H-ras in human gastric cancer and colon cancer.

International journal of biological sciencesĀ·2010
Same author

Nano-sized SnSbAgx alloy anodes prepared by reductive co-precipitation method used as lithium-ion battery materials.

Journal of nanoscience and nanotechnologyĀ·2010
Same author

Complementary diffusion tensor imaging study of the corpus callosum in patients with first-episode and chronic schizophrenia.

Journal of psychiatry & neuroscience : JPNĀ·2010

Related Experiment Video

Updated: Feb 9, 2026

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
13:04

Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

Published on: March 1, 2019

9.3K

[Regulative Role For Noncoding RNAs During Skeletal Muscle Development and Disease].

Sheng-Ju Chen, Fei Wang, Yue Zhou

    Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
    |June 13, 2018
    PubMed
    Summary

    Noncoding RNAs regulate muscle development and disease. Circulating noncoding RNAs show promise as biomarkers for early disease diagnosis and potential therapeutic targets.

    More Related Videos

    Isolation of Small Noncoding RNAs from Human Serum
    06:44

    Isolation of Small Noncoding RNAs from Human Serum

    Published on: June 19, 2014

    18.6K
    Tissue Triage and Freezing for Models of Skeletal Muscle Disease
    05:58

    Tissue Triage and Freezing for Models of Skeletal Muscle Disease

    Published on: July 15, 2014

    41.3K

    Related Experiment Videos

    Last Updated: Feb 9, 2026

    Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR
    13:04

    Overexpressing Long Noncoding RNAs Using Gene-activating CRISPR

    Published on: March 1, 2019

    9.3K
    Isolation of Small Noncoding RNAs from Human Serum
    06:44

    Isolation of Small Noncoding RNAs from Human Serum

    Published on: June 19, 2014

    18.6K
    Tissue Triage and Freezing for Models of Skeletal Muscle Disease
    05:58

    Tissue Triage and Freezing for Models of Skeletal Muscle Disease

    Published on: July 15, 2014

    41.3K

    Area of Science:

    • Molecular Biology
    • Biochemistry
    • Genetics

    Background:

    • Noncoding RNAs (ncRNAs), encompassing long noncoding RNAs (lncRNAs) and microRNAs (miRNAs), play crucial roles in myogenesis.
    • These molecules are implicated in regulating skeletal muscle fiber type determination and the pathogenesis of various muscle diseases.

    Purpose of the Study:

    • To highlight the significance of ncRNAs in skeletal muscle development.
    • To underscore the potential of circulating ncRNAs as biomarkers for disease screening and early diagnosis.
    • To explore future therapeutic applications targeting ncRNAs in muscle disorders.

    Main Methods:

    • Literature review and synthesis of existing research on ncRNAs in muscle biology.
    • Analysis of studies investigating the role of lncRNAs and miRNAs in myogenesis.
    • Examination of data on circulating ncRNAs as potential biomarkers.

    Main Results:

    • ncRNAs are key regulators of skeletal muscle differentiation and function.
    • Circulating ncRNAs are emerging as promising, non-invasive biomarkers for disease detection.
    • Dysregulation of specific ncRNAs is associated with the development of muscle pathologies.

    Conclusions:

    • Noncoding RNAs are integral to skeletal muscle development and health.
    • Circulating ncRNAs offer a novel avenue for early disease detection and monitoring.
    • Targeting ncRNAs presents a promising future strategy for treating muscle diseases.