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Infection Retardant Coatings Impact on Bacterial Presence in Penile Prosthesis Surgery: A Multicenter Study

Kavina Jani1, Christopher Smith2, John R Delk3

  • 1ArkLaTex Urology, Bossier City, LA.

Urology
|June 13, 2018
PubMed
Abstract

Insights

Infection retardant coatings (IRC) on penile prostheses (PPs) were associated with fewer positive bacterial cultures, particularly Staphylococcus, in noninfected patients undergoing revision surgery. IRC PPs showed a different bacterial profile in infected patients as well.

Area of Science:

  • Urology
  • Infectious Diseases
  • Biomaterials Science

Background:

  • Penile prostheses (PPs) are used to treat erectile dysfunction.
  • Infection is a significant complication following PP implantation.
  • Infection retardant coatings (IRC) are designed to reduce the risk of PP infection.

Purpose of the Study:

  • To compare positive culture rates in patients with and without IRC PPs.
  • To analyze changes in bacterial isolates from PPs in patients with overt clinical infection.
  • To evaluate the efficacy of IRC PPs in preventing bacterial colonization.

Main Methods:

  • Cultures were obtained from PPs during surgical exposure in 236 patients.
  • Patients were divided into noninfected (208) and infected (28) groups.
  • Subgroups included those with uncoated PPs and IRC PPs; bacterial isolate sensitivity to tetracycline and rifampin was assessed.

Main Results:

  • Noninfected patients with IRC PPs had significantly lower positive culture rates (32/75) compared to those with uncoated PPs (85/133) [P=0.0003].
  • Staphylococcus genus isolates were less common in noninfected patients with IRC PPs (20/75) versus uncoated PPs (75/133).
  • In infected patients, culture rates and Staphylococcus prevalence did not differ significantly between uncoated and IRC PPs.

Conclusions:

  • Clinically uninfected PPs can harbor positive bacterial cultures during revision surgery.
  • IRC PPs demonstrate a distinct bacterial profile, with a reduction in Staphylococcus genus isolates, even in the absence of overt infection.
  • IRC PPs may alter the bacterial colonization patterns on penile prostheses.

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