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Glycophagy: An emerging target in pathology
Hong Zhao1, Mingzhu Tang1, Meiqing Liu1
1Institute of Pharmacy and Pharmacology, Hunan Province Cooperative Innovation Center for Molecular Target New Drugs Study, University of South China, Hengyang 421001, China.
Summary
Glycophagy, a selective autophagy process, is vital for glucose homeostasis and involves STBD1. This review explores its role in Pompe disease and diabetic cardiomyopathy, suggesting therapeutic potential.
Area of Science:
- Cellular Biology
- Metabolism
- Autophagy
Background:
- Autophagy is a conserved cellular process involving self-digestion.
- Selective autophagy pathways, including glycophagy, have been identified.
- Glycophagy is crucial for glucose homeostasis in key tissues like the heart, liver, and skeletal muscles.
Purpose of the Study:
- To review the occurrence, development, and regulatory mechanisms of glycophagy.
- To analyze the dual role of glycophagy in Pompe disease and diabetic cardiomyopathy.
- To explore the therapeutic potential of targeting glycophagy.
Main Methods:
- Literature review focusing on glycophagy research.
- Analysis of signaling pathways regulating glycophagy (e.g., cAMP/PKA, PI3K-Akt/PKB-mTOR, Calcium).
- Investigation of STBD1 and GABARAPL1 interaction in glycophagy initiation.
Main Results:
- Glycophagy is regulated by multiple signaling pathways.
- STBD1 initiates glycophagy by tethering glycogen to membranes via GABARAPL1.
- Glycophagy plays a protective role in Pompe disease but may worsen diabetic cardiomyopathy via the FoxO1 pathway.
Conclusions:
- Glycophagy is a critical selective autophagy process with complex regulatory mechanisms.
- Targeting glycophagy presents a potential therapeutic strategy for glycogen storage diseases and diabetic cardiomyopathy.
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